Details About Generic Salt ::  Ondanset

Main Medicine Class:: Antiemetic,antivertigo   

(ahn-DAN-SEH-trahn HIGH-droe-KLOR-ide)
Zofran
Zofran ODT
Class: Antiemetic/antivertigo

 

Drugs Class ::

 Action Selective serotonin (5-HT3) receptor antagonist that inhibits serotonin receptors in GI tract or chemoreceptor trigger zone.

Indications for Drugs ::

 Indications

Parenteral and oral: Prevention of nausea and vomiting with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin; prevention of postoperative nausea or vomiting. Oral: Prevention of nausea and vomiting associated with radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen; prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including cisplatin ³ 50 mg/m2. Unlabeled use(s): Treatment of nausea and vomiting associated with acetaminophen poisoning or prostacyclin therapy; treatment of acute levodopa-induced psychosis (visual hallucinations); reduction in bulimic episodes due to bulimia nervosa; treatment of spinal or epidural morphine-induced pruritus; management of social anxiety disorder.

Drug Dose ::

 Route/Dosage

Prevention of Chemotherapy-Induced Nausea and Vomiting

ADULTS: IV 0.15 mg/kg infused over 15 min beginning 30 min before emetogenic chemotherapy with 2 additional 0.15 mg/kg doses 4 and 8 hrs after the first dose. Alternatively, infuse 32 mg over 15 min, starting 30 min prior to emetogenic chemotherapy. ADULTS & CHILDREN ³ 12 YR: PO (moderately emetogenic cancer chemotherapy) 8 mg bid, administering the first dose 30 min prior to starting emetogenic chemotherapy and the second dose 8 hrs after the first dose; subsequent 8 mg doses may be given q 12 hr for 1 to 2 days after completion of chemotherapy. CHILDREN 4 to 11 YR: PO 4 mg tid, starting 30 min prior to chemotherapy, with subsequent doses 4 and 8 hr after the first dose; give 4 mg q 8 hr for 1 to 2 days after completion of chemotherapy.

Prevention of Radiotherapy-Induced Nausea and Vomiting

ADULTS: PO 8 mg tid.

Total Body Irradiation

ADULTS: PO 8 mg 1 to 2 hr prior to each fraction of radiotherapy administered each day.

Single High-Dose Fraction Radiothreapy to the Abdomen

ADULTS: PO 8 mg 1 to 2 hr prior to radiotherapy, with subsequent doses q 8 hr after the first dose for 1 to 2 days after completion of radiotherapy.

Daily Fractionated Radiotherapy to the Abdomen

ADULTS: PO 8 mg 1 to 2 hr prior to radiotherapy, with subsequent doses q 8 hr after the first dose for each day radiotherapy is given.

Prevention of Postoperative Nausea and Vomiting

ADULTS: IV 4 mg (undiluted) > 30 sec (preferably over 2 to 5 min) or IM 4 mg (undiluted) as a single injection. PO 16 mg as a single dose 1 hr prior to induction of anesthesia. CHILDREN (2 to 12 YR weighing £ 40 kg): IV 0.1 mg/kg CHILDREN (> 40 kg): IV 4 mg single dose. Administer over ³ 30 sec, preferably over 2 to 5 min.

Prevention of Nausea and Vomiting due to Highly Emetogenic Cancer Chemotherapy

ADULTS: PO 24 mg given 30 min prior to start of single-day highly emetogenic chemotherapy, including ³ 50 mg/m2 cisplatin.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Undetermined. Children: Dosing in children < 4 yr is not well defined. Hepatic impairment: In patients with severe hepatic impairment, do not exceed 8 mg daily oral dose. For IV use, give single 8 mg daily dose over 15 min beginning 30 min before chemotherapy. Peristalsis: Ondansetron does not stimulate gastric or intestinal peristalsis; may mask progressive ileus or gastric distention.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Chest pain; tachycardia. CNS: Headache; seizures. DERM: Rash. GI: Dry mouth; constipation; abdominal pain. META: Hypokalemia. RESP: Bronchospasm. OTHER: Fever; anaphylaxis; weakness.

Drug Mode of Action ::  

 Action Selective serotonin (5-HT3) receptor antagonist that inhibits serotonin receptors in GI tract or chemoreceptor trigger zone.

Drug Interactions ::

 Interactions

Rifamycins (eg, rifampin): Plasma levels of ondansetron may be reduced, decreasing the antiemetic effect. INCOMPATIBILITIES: Alkaline solutions.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note hepatic impairment.
  • Ensure that baseline hepatic studies have been performed before beginning therapy.
  • Assess patient for nausea, vomiting, and bowel sounds.
  • Monitor I&O carefully.
  • Be prepared to give additional IV fluids to patient who is vomiting, but do not overhydrate.
  • Discontinue IV infusion if signs of hypersensitivity develop.
OVERDOSAGE: SIGNS & SYMPTOMS
  Hypotension, constipation

Drug Storage/Management ::

 Administration/Storage

  • Dilute solution in 50 mL of 5% Dextrose in Water or 0.9% Sodium Chloride for Injection.
  • Do not mix with solutions for which compatibility has not been established.
  • Preparation is stable for 48 hr at room temperature following dilution.
  • Rectal suppositories and oral solutions may be extemporaneously compounded.

Drug Notes ::

 Patient/Family Education

  • Advise patient that headache is a common side effect.
  • Advise patient that medication will greatly reduce likelihood of nausea and vomiting, but that these are still possible.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

DOWNLOAD OUR ANDROID APP

One of the 1st in India.High Quality Generic Medicine Portal Android Application for Online Oreder & Information.

For More Join Our Membership and Get Additional 25% off on Meds, also get MLM Benefits to get a permanent earning source.

Join Membership How to Search Medicine
Android App

We would like to keep you updated with special notifications.