Details About Generic Salt ::  Trovaflo

Main Medicine Class:: Antibiotic,Fluoroquinolone   

(TROE-vah-FLOX-ah-sin MEH-sih-LATE/al-at-row-FLOX-ah-sin)
Trovan, Tablets
Class: Antibiotic/Fluoroquinolone


Drugs Class ::

 Action The IV form is rapidly converted to trovafloxacin, which interferes with microbial DNA synthesis.

Indications for Drugs ::

 Indications Treatment of nosocomial pneumonia, community-acquired pneumonia, complicated intra-abdominal infections, complicated skin and skin structure infections, gynecologic, and pelvic infections caused by susceptible organisms.

Drug Dose ::


Nosocomial Pneumonia

ADULTS: IV 300 mg followed by PO 200 mg q 24 hr for 10 to 14 days.

Community Acquired Pneumonia

ADULTS: PO/IV 200 mg followed by PO 200 mg q 24 hr for 7 to 14 days.

Complicated Intra-Abdominal; Gynecologic; Pelvic Infections

ADULTS: IV 300 mg followed by PO 200 mg q 24 hr for 7 to 14 days.

Complicated Skin and Skin Structure Infections

ADULTS: PO/IV 200 mg followed by PO 200 mg q 24 hr for 10 to 14 days.

Contraindication ::

 Contraindications Hypersensitivity to fluoroquinolones, quinolone antibiotics, or any product component; tendonitis or tendon rupture associated with quinolone use.

Drug Precautions ::


Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Safety and efficacy in children < 18 yr not established. Convulsions: CNS stimulation can occur; use drug with caution in patients with known or suspected CNS disorder. Hypersensitivity reactions: Serious and potentially fatal reactions have occurred. Photosensitivity: Moderate to severe reactions may occur. Pseudomembranous colitis: Consider possibility in patients who develop diarrhea. Superinfections: Use of antibiotics may result in bacterial or fungal overgrowth. Hepatic function impairments: Dosage reduction is recommended for patients with mild or moderate cirrhosis. Refer to manufacturer’s package insert for dose calculations. There is no information regarding use in patients with severe cirrhosis. Liver function tests: Oral use: Elevation of liver function tests have occurred during or soon after prolonged therapy (> 21 days). Long-term safety: Safety and efficacy of therapy given for > 4 wk have not been studied. Hepatic injury: Serious liver injury leading to transplantation and death have been reported with short- and long-term exposure to trovafloxacin; do not administer for > 2 wk.


Drug Side Effects ::

 Adverse Reactions

CNS: Headache; dizziness; lightheadedness. DERM: Pruritis; rash (IV use). GI: Nausea; diarrhea; vomiting; abdominal pain. GU: Vaginitis (oral use). OTHER: Application/injection/insertion site reaction (IV use).

Drug Mode of Action ::  

 Action The IV form is rapidly converted to trovafloxacin, which interferes with microbial DNA synthesis.

Drug Interactions ::


Magnesium-aluminum-containing antacids, antacids containing citric acid buffered with sodium citrate, iron salts, vitamins/minerals containing iron, sucralfate: May decrease oral absorption of trovafloxacin. Stagger administration times by ³ 2 hr. IV morphine sulfate: May decrease oral absorption of trovafloxacin. Administer IV morphine 2 hr after administration of trovafloxacin in fasted state or 4 hr after administration with food.

Drug Assesment ::


  • Limit the use of trovafloxacin/alatrofloxacin to patients who receive initial treatment in a hospital or long-term nursing facility.
  • Obtain patient history, including drug history and any known allergies. Note hepatic impairment.
  • Monitor for signs of infection throughout course of therapy.
  • Monitor I&O.
  • Monitor for signs of anaphylaxis (pharyngeal or facial edema, dyspnea, urticaria and itching, hypotension).
  • Monitor for symptoms of pseudomembranous colitis (loose or foul-smelling stools) or symptoms of CNS stimulation (tremor, restlessness, confusion).

Drug Storage/Management ::


Oral use:

  • Do not administer for > 2 wk.
  • Administer without regard to food with full glass of water.
  • Administer 2 hr before or after antacids containing magnesium or aluminum; antacids containing citric acid buffered with sodium citrate, sucralfate; vitamins or minerals with iron, iron salts.
  • Administer IV morphine sulfate 2 hr after trovafloxacin is administered without food or 4 hr after administration with food.
  • Store at room temperature in tightly closed container.

IV use:

  • Do not administer for > 2 wk.
  • For IV administration only. Do not administer via intramuscular, intrathecal, intraperitoneal, or subcutaneous route.
  • Must be diluted with appropriate solution before administration. Refer to the manufacturer’s package insert for compatible fluids and dilution guidelines.
  • Infuse over 60 min. Avoid rapid or bolus injection.
  • Do not use if particulate matter or discoloration is noted.
  • Other medications or additives should not be combined with alatrofloxacin nor infused simultaneously through the same IV line.
  • If same IV line is used for sequential infusion of several different drugs, the line should be flushed before and after each medication with a mutually compatible solution.
  • Discard any unused solution.
  • Patients started on alatrofloxacin may be switched to trovafloxacin tablets, using comparable dosages (ie, no adjustment necessary), when clinically indicated at the discretion of the physician.
  • Store undiluted vials at room temperature protected from light. Do not freeze.
  • Diluted solution is stable for 3 days at room temperature or 7 days when refrigerated.

Drug Notes ::

 Patient/Family Education

Oral use:

  • Inform patient that tablets may be taken orally without regard to meals.
  • Inform patient to take tablets 2 hr before or after antacids containing magnesium or aluminum, citric acid buffered with sodium citrate, sucralfate, vitamins and minerals containing iron and iron salts.
  • Caution patient to avoid exposure to sunlight, and to use sunscreen or protective clothing until tolerance is determined.
  • Instruct patient to report any signs of bacterial or fungal overgrowth (lack, furry appearance of tongue, vaginal itching or discharge, loose or foul-smelling stools).
  • Caution patient that drug may cause dizziness or lightheadedness and to use caution while driving or performing other tasks requiring mental alertness.
  • Emphasize importance of completing entire dose regimen.
  • Instruct patient to discontinue treatment and inform physician if experiencing any of the following: pain, inflammation or rupture of a tendon; kin rash or hives; difficulty swallowing or breathing; swelling of lips, tongue, or face; tightness of throat.
  • Instruct patient to notify physician if experiencing persistent diarrhea or diarrhea containing mucus.

IV use:

  • Inform patient that IV form is administered until physician decides it is appropriate to convert to oral therapy with trovafloxacin.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


One of the 1st in India.High Quality Generic Medicine Portal Android Application for Online Oreder & Information.

For More Join Our Membership and Get Additional 25% off on Meds, also get MLM Benefits to get a permanent earning source.

Join Membership How to Search Medicine
Android App

We would like to keep you updated with special notifications.