The Brand Name AZOPRINE Has Generic Salt :: Azathioprine 

AZOPRINE  Is From Company Vhb Priced :: Rs. 724

AZOPRINE have Azathioprine is comes under Sub class Immunuosuppressants of  Main Class Immunology , Allergy

Main Medicine Class:: Immunology , Allergy  Sub Medicine Class :: Immunuosuppressants 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Azathioprine  TAB  Rs. 724  100
Brand Name Company / Manufacturers Strength Unit Price / 100
 AZOPRINE  Vhb  50MG  100 Rs. 724

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Vhb :: AZOPRINE  Azathioprine  Immunology , Allergy Immunuosuppressants

Indications for Drugs ::

Rheumatoid arthritis, Prevention of rejection in organ and tissue transplantation, Auto-immune diseases, Renal homotransplantation

Drug Dose ::

Adult: PO Rheumatoid arthritis Initial: 1 mg/kg/day for 6-8 wk. May adjust dose gradually to 2.5 mg/kg/day if needed. Prevention of rejection in organ and tissue transplantation 1-5 mg/kg/day. Auto-immune diseases 1-3 mg/kg/day.

Contraindication ::

Hypersensitivity; previous treatment with alkylating agents; pregnancy, lactation.

Drug Precautions ::

Increased risk of serious infections and neoplasia in chronic immunosuppression; leucopenia, thrombocytopenia, renal or hepatic impairment. Increased risk of haematologic toxicity in patients with thiopurine methyltransferase deficiency. Monitor CBC (including platelet count) wkly during 1st mth, twice mthly for 2nd and 3rd mth, then mthly; monitor more frequently if there are dosage adjustments. Monitor LFT periodically; discontinue treatment if jaundice occurs. Reduce dose promptly or withdraw drug temporary if there is rapid decrease/persistently low WBC or signs of bone marrow depression. Dose reduction may be necessary in patients with reduced TPMT (thiopurine methyltransferase) activity.

Drug Side Effects ::

Fever, chills; bone marrow depression characterised by leucopenia, thrombocytopenia or anaemia; anorexia, nausea, diarrhoea; arthralgias; secondary infections; hepatotoxicity, rash, alopoecia. Potentially Fatal: Myelosuppression, mutagenicity and carcinogenicity; veno-occlussive liver disease.

Pregnancy category ::
Pregnancy category


Drug Mode of Action ::  

Azathioprine is an imidazolyl derivative of mercaptopurine, which inhibits DNA, RNA and protein synthesis and antagonises purine synthesis. It also inhibits mitosis and interferes with cellular metabolism of susceptible organisms. Azathioprine inj should be converted to oral therapy as soon as the drug can be tolerated.

Drug Interactions ::

Increased risk of haematotoxicity with aminosalicylates, drugs that affect myelopoesis e.g. co-trimoxazole or trimethoprim. Increased risk of infections with intra-uterine devices and live vaccines. Increased risk of leucopenia with ACE inhibitors. Concurrent use may reduce the anticoagulant effect of vitamin K antagonists e.g. warfarin. Increased risk of myelosuppressive effects when used with drugs that inhibit TPMT (thiopurine methyltransferase) or xanthine oxidase e.g. olsalazine, allopurinol. Potentially Fatal: Increased risk of serious haematotoxicity or hepatotoxicity with leflunomide. Increased risk of bone marrow suppression with mycophenolate mofetil. Increased risk of infections and malignancies with efalizumab.


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