Indications & Dose: ACUTE SINUSITIS/TYPHOID FEVER PO Adult 500mg BID 10 days | ACUTE UNCOMPLICATED UTI/CYSTITIS PO Adult IR: 250mg BID 3 days, ER: 500mg/day 3 days | IV Adult 200mg BID 1-2 wk | ANTHRAX Postexposure prophylaxis PO Adult IR: 500mg BID 60 days Child IR: 10-15mg/kg BID 60 days, max 500mg/doseCutaneous | Postexposure prophylaxis IV Adult 400mg BID 60 days Child 10-15mg/kg BID 60 daysInhalation | BACTERIAL CONJUNCTIVITIS TP Adult Solution: Instill 1-2 drops in eye(s) q2h while awake for 2 days and 1-2 drops q4h next 5 days Child >1 yr: Same as adult dose | TP Adult Ointment: Apply 1/2” ribbon into the conjunctival sac TID for the first 2 days, then BID next 5 days Child >2 yr: Same as adult dose | BACTERIAL PROSTATITIS Chronic PO Adult 500mg BID 28 days | BARTONELLA INFECT (CAT SCRATCH DISEASE) PO Adult 500mg BID 10-16 days | BONE & JOINT INFECT PO Adult 500-750mg BID 4-6 wk | IV Adult 400mg BID/TID 4-6 wk | CHANCROID PO Adult 500mg BID 3 days | COMPLICATED UTI/PYELONEPHRITIS PO Adult IR: 500mg BID 1-2 wk, ER: 1g OD 1-2 wk Child 20-30mg/kg/day in 2 divided doses q12h 10-21 days, max 1.5g/day | IV Adult 400mg BID 1-2 wk Child 6-10mg/kg TID 10-21 days, max 400mg/dose | CORNEAL ULCER TP Adult Solution: Instill 2 drops into eye q15 min for first 6h, then 2 drops into the eye q30 min for remainder of the first day. Day 2: Instill 2 drops q1h. Days 3-14: Instill 2 drops into q4h. Continue therapy if there is no re-epithelialization Child >1 yr: Same as adult dose | CROHN’S DISEASE PO Adult 500mg BID | DISSEMINATED GONOCOCCAL INFECT PO Adult 500mg BID 1 wk | ENDOCARDITIS PO Adult 500mg BID 4 wk Child 20-30mg/kg in 2 divided doses | FEBRILE NEUTROPENIA IV Adult 400mg TID 1-2 wk | GRANULOMA INGUINALE (DONOVANOSIS) PO Adult 750mg BID 3 wk | INFECT DIARRHEA PO Adult Salmonella 500mg BID 5-7 days, Shigella 500mg BID 3 days, Mild Traveler’s 750mg one dose, Severe Traveler’s 500mg BID 3 days, Vibrio cholera 1g single dose | INFECT IN HIV PATIENTS PO Adult Travelers’ diarrhea (empirical therapy) 500mg BID 3-7 days, Septicemia recurrence long-term prophylaxis: 500mg BID | LEGIONNAIRES’ DISEASE PO Adult 500mg BID 2-3 wk | IV Adult 400mg BID 2-3 wk | LOWER RESPIRATORY TRACT INFECT PO Adult 500-750mg BID 1-2 wk | IV Adult 400mg BID 1-2 wk for mild-to-moderate infect, 400mg TID 1-2 wk for severe infect | MALIGNANT OTITIS EXTERNA PO Adult 750mg BID 6-8 wk | MENINGITIS PO Adult 500mg BID 5 days | SKIN/SKIN STRUCTURE INFECT PO Adult 500-750mg BID 1-2 wk | IV Adult 400mg BID 1-2 wk for mild-to-moderate infect, 400mg TID 1-2 wk for severe infect | SURGICAL PROPHYLAXIS PO/IV Adult 500/400mg before procedure | TREATMENT OF OTITIS EXTERNA, CHRONIC SUPPURATIVE OTITIS MEDIA TP Adult Ear drops containing 0.2 or 0.3% of ciprofloxacin, usually used in combination with corticosteroids | TULAREMIA/PLAGUE PO Adult 500mg BID 2 wk Child 20mg/kg BID, max 1g/day 2 wk | IV Adult 400mg BID 2 wk Child 15mg/kg BID, max 1g/day 10-14 days | URETHRAL/CERVICAL GONOCOCCAL INFECT PO Adult 250-500mg single dose

Precautions: patients with epilepsy/ history of CNS disorders, renal impairment, G6PD deficiency, myasthenia gravis, tendon damage, QT prolongation, electrolyte disturbances, bradycardia, pre-existing cardiac disease, avoid exposure to strong sunlight/sunlamps

ADR: Serious: pseudomembranous colitis, pancreatitis, hallucinations, psychotic reactions, depression, convulsions, hepatitis, eosinophilia, paresthesia, peripheral neuropathy, vasculitis, SJS, TEN, photosensitivity, ARF, ventricular arrhythmias, prolongation of the QT interval, Others: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, dysphagia, headache, dizziness, drowsiness, rash

DDI: Serious Cyclophosphamide active metabolite decreases by drug, Corticosteroids increases risk of severe tendon disorders in elders, Methotrexate level increases, Sucralfate/Iron compounds/Zinc compounds reduces drug absorption, Didanosine/Calcium compounds/Sevelamer reduces drug bioavailability

Diet: 2h after food

Monitor: CBC, renal function test, LFTs (prolonged therapy)