Indications & Dose: ANTHRAX IV/PO Adult 500mg OD Child =>6 months: 8mg/kg q12h 2monthsInhalational, Postexposure | COMMUNITY-ACQUIRED PNEUMONIA PO/IV Adult 500mg/day 7–14 days | CONJUNCTIVITIS TP Adult Solution (0.5%): Day 1& 2: Instill 1-2 drops into affected eye q2h while awake 8 times/day, Day 3-7: Instill 1-2 drops into affected eye q4h while awake, 4 times/day Child >1 yr: Same as adult dose | CORNEAL ULCER TP Adult Solution (1.5%) Day 1-3: Instill 1-2 drops into affected eye q30mins-2h while awake & 4-6h after retiring, Day 4-completion: Instill 1-2 drops into affected eye q1-4h while awake Child =>6 yr: Same as adult dose | DIVERTICULITIS PO/IV Adult 750mg OD 7-10 days | DYSENTERIC ENTEROCOLITIS PO/IV Adult 500mg q24h 3-5 daysSHIGELLA SPP | EPIDIDYMITIS PO Adult 500mg/day 10 daysNongonococcal | EXACERBATION OF CHRONIC BRONCHITIS Chronic PO/IV Adult 500mg/day 7 days | GONOCOCCAL INFECTION IV Adult 250mg OD, if symptoms improve after 24h increase dose to 500mg(PO) for q24h to complete therapy of 7 daysDisseminated infection | NOSOCOMIAL PNEUMONIA PO Adult 750mg/day 7-14 days | PERITONITIS PO/IV Adult 750mg q24h 7-10 days | PROSTATITIS Chronic PO Adult 500mg OD 28 days | SINUSITIS Acute PO Adult 500mg/day 10–14 days | SKIN/SKIN STRUCTURE INFECT Uncomplicated PO/IV Adult 500mg OD 7-10 days | Complicated PO/IV Adult 750mg OD 7-14 days | URETHRITIS PO Adult 500mg /day 7 daysNongonococcal | URINARY TRACT INFECT Uncomplicated PO Adult 250mg/day 3 days | Complicated PO/IV Adult 250mg/day 10 days or 750 mg/day for 5 daysincluding pyelonephritis

Precautions: CVD, hepatic/renal impairment, history of epilepsy, myasthenia gravis

ADR: Serious: SJS, TEN, thrombocytopenia, hepatic dysfunction, hypotension, convulsions, rhabdomyolysis, renal failure, arthralgia, myalgia, Others: dyspnea, paresthesia, taste disturbances, constipation, vomiting, nausea, diarrhea, dyspepsia, drowsiness, flatulence, abdominal pain, confusion, anxiety, depression, hallucinations, fever, tremor

DDI: Serious Glibenclamide causes hypoglycemia, Levofloxacin/Amiodarone/Procainamide causes Torsade de pointes, Probenecid increases drug levels, Ferrous Sulphate reduces drug bioavailability

Diet: With/without food

Monitor: Renal function test, LFT & hematopoietic function, WBC & signs of infection