Indications & Dose: HEART FAILURE PO Adult Initially 2.5-5mg OD, then increase by no more than 10mg increments at intervals not less than 2 wk to max 40mg/day, MD 5-40mg/day as single dose | HYPERTENSION PO Adult 10-40mg/day Child >6 yr: Initially 0.07mg/kg OD, increase dose at 1- 2wk intervals Elderly Initially 2.5-5mg/day, may be increased at 1-2 wk interval max 40mg/day

Precautions: Aortic stenosis, CVD, patients with collagen vascular disease, hypertrophic cardiomyopathy with outflow tract obstruction, unstented unilateral/bilateral renal artery stenosis, renal impairment, hyperkalemia, concurrent use of angiotensin receptor blockers, pediatrics, before, during/immediately after major surgery

ADR: Serious: Hypotension, ARF, angioedema, hepatic necrosis, peripheral neuropathy, stroke, SJS, TEN, thrombocytopenia, SIADH, hyperkalemia, Others: Headache, dizziness, fatigue, rash, impotence, diarrhea, nausea, vomiting, abdominal pain, decreased hemoglobin, chest pain, weakness, BUN increased, cough, URTI, alopecia, anuria, mood changes, transaminases increased, xerostomia, weight gain/loss, vision loss, wheezing, urticaria, volume overload

DDI: Serious Atorvastatin causes acute pancreatitis, Clozapine causes additive hypotensive effects, Lovastatin causes severe hyperkalemia, Hydrochlorothiazide/Furosemide leads to acute renal failure, Antidiabetics leads to hypoglycemia, Tizanidine/Pergolide leads to severe hypotension, Lithium toxicity raises

Monitor: BUN, Secr, renal function, WBC, potassium, CBC with differential