Indications & Dose: ACID ASPIRATION SYNDROME PO General 150mg 2h before the induction of anesthesia, also preferably 150mg the previous eveningDuring GA | BENIGN GASTRIC/DUODENAL ULCER PO Adult 150mg BID, MD 150mg HS Child Neonate: 2mg/kg TID, max 3mg/kg TID, 1-6 months: 1mg/kg TID, 6 months-3 yr: 2–4mg/kg BID, 3-12 yr: 2-4mg/kg BID, max 150mg, 12-18 yr: 150mg BID/300mg HS | EPISODIC DYSPEPSIA Chronic PO Adult 150mg BID 6 wk | EROSIVE ESOPHAGITIS PO Adult 150mg QID, MD 150mg BID Child 5-10mg/kg/day BID in divided dose max 600mg/day | GASTROESOPHAGEAL REFLUX DISEASE PO Adult 150mg BID Child 5-10mg/kg/day BID in divided dose, max 300mg/day | H.PYLORI ERADICATION Combination therapy PO Adult 150mg BID | H.PYLORI INFECT PO Adult 150mg TID/300mg OD HS, MD 150mg OD Child 4-8mg/kg/day BID in divided doses, max 300mg OD, MD 2-4mg/kg/day OD, max 150mg/day | HEART BURN Prophylactic therapy PO Adult 75mg, max 150mg/day Child > 12 yr: Same as adult dose | NSAID-INDUCED GASTRIC ULCERS Prophylactic therapy PO General 150mg BID during therapy | PATHOLOGICAL HYPERSECRETORY CONDITIONS PO Adult 150mg BID, max 6g/day | STRESS ULCERATION IV Adult 50mg priming dose followed by continuous inf 125-250µg/kg/h. 150mg PO BID after oral feeding is resumedSlow intravenous | ZOLLINGER-ELLISON IV Adult Inf: Initially 1mg/kg/h, measure gastric acid output at 4h, if >10 mEq or if patient is symptomatic, increase dose in increments of 0.5mg/kg/h, dose up to 2.5mg/kg/h may be used:

Precautions: Hepatic /renal impairment, heart rhythm disturbances, phenylketonuria, elderly

ADR: Serious: AV block, bradycardia, vasculitis, acquired immune hemolytic anemia, acute interstitial nephritis, anaphylaxis, agranulocytosis, hypersensitivity, Others: erythema multiforme, rash, headache, insomnia, mental confusion

DDI: Serious Propantheline increases drug level

Diet: With/without food

Monitor: LFTs, Se Cr, signs and symptoms of PUD