ACUTE COMPLICATIONS OF DIABETES MELLITUS (DKA) DKA is characterized by the triad of hyperglycemia, anion gap metabolic acidosis, and ketonemia. Metabolic acidosis is often the major finding. The serum glucose concentration is usually greater than 500 mg/dL (27.8 mmol/L) and less than 800 mg/dL (44.4 mmol/L) . However, serum glucose...
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HYPERGLYCEMIC HYPEROSMOLAR STATE (HHS) hyperosmolar hyperglycemic state (HHS, also known as nonketotic hyperglycemia) and Diabetic ketoacidosis (DKA) are of the most serious acute complications of diabetes. hyperosmolar hyperglycemic state (HHS, also called nonketotic hyperglycemia) In HHS, there is little or no ketoacid accumulation, the serum glucose concentration frequently exceeds 1000...
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CHRONIC COMPLICATIONS OF DIABETES MELLITUS COMMON DISEASES DUE TO DM HYPERGLYCEMIA AND MICROVASCULAR DISEASE — Hyperglycemia is an important risk factor for the development of microvascular disease in patients with type 2 diabetes, as it is in patients with type 1 diabetes. Chronic Long-term complications result in morbidity and mortality. Children...
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Grave’s disease Grave’s disease is thyrotoxicosis, common in females, associated with high iodine intake, occurring between 20 – 50 years of age. Grave’s ophthalmopathy Besides the signs of thyrotoxicosis, there is Grave’s ophthalmopathy. decreased extraocular muscle mobility, and corneal injury, periorbital edema, periorbital and conjunctival inflammation, Ophthalmopathy associated with hyperthyroidism...
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Thyrotoxic crisis or thyroid storm It is a life-threatening hyperthyroidism with fever, seizures, coma, vomiting, diarrhoea, jaundice. A rare but often life-threatening medical emergency resulting from untreated hyperthyroidism Death can occur due to cardiac failure, arrhythmias, hyperthermia. Thyrotoxic crisis Symptoms include : — and fingernails may separate from the nail...
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GOITER of THYROID Acute thyroiditis is an inflammatory condition of thyroid due to suppurative infection. enlarged thyroid gland may be caused by thyroiditis, benign thyroid nodules, malignancy, iodine deficiency, or any condition that causes hyperfunction or hypofunction of the gland Types of GOITER aberrant goiter: A supernumerary goiter. acute goiter:...
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Adrenal Gland Diseases 9V7GZUQ7PBG5 The adrenal cortex produces 3 steroids: 9V7GZUQ7PBG5 9V7GZUQ7PBG5 1. Glucocorticoids 2. Mineralocorticoids 3. Adrenal androgens The function of these steroids are: 1. Glucocorticoids – modulate intermediary metabolism and immune responses of the body. 2. Mineralocorticoids – Regulate blood pressure, vascular volume and electrolytes. 3. Adrenal androgens...
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LABORATORY TESTS FOR ADRENAL FUNCTION · Tests of pituitary adrenal responsiveness. · Suppression tests -are measurement of target hormone response after suppression of its tropic hormone. · Stimulation tests · Plasma ‘Levels of ACTH and angiotensin II. · Measurement of urinary free cortisol · Measurement of urinary creatinine · Measurement...
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Aldosteronism Clinical features Causes and Treatment definition Aldosteronism is a syndrome with hypersecretion of mineralocorticoid aldosterone. Primary aldosteronism is excessive aldosterone production due to disease of adrenal glands. It is also called nodular hyperplasia or idiopathic hyperaldosteronism. Nonsuppressible (primary) hypersecretion of aldosterone is a underdiagnosed cause of hypertension. There...
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DISORDERS OF GROWTH AND DEVELOPMENT Growth is dependent on GH, IGF, sex steroids, thyroid hormones, paracrine growth factors and cytokines. Growth also requires caloric energy, amino acids, vitamins and trace metals. Short stature results due to intrinsic and extrinsic factors which impair growth. Growth GHD Causes may be : Most common...
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