Adenosine

Details About Generic Salt ::  Adenosine 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Anti Arrhythmics

4B. ANTI-ARRHYTHMICS in 4. CARDIOVASCULAR SYSTEM
ADENOSINE
ENDOGENOUS NUCLEOSIDE | ANTI-ARRHYTHMIC
PK: M: Blood & tissue

Indications & Dose: ADJUNCT TO THALLIUM STRESS TESTING IV Adult 140µg/kg/min over 6 min Via peripheral veinInfusion | DIFFERENTIAL DIAGNOSIS OF SVT IV General 3mg, then 6-12mg (given at 1-2 min intervals if required) | MYOCARDIAL IMAGING IV Adult Inf: 140µg/kg/min for 6 min, inject radionuclide after 3 min of infusion | PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA IV Adult Initially 6mg (reduce to 3mg if patient is receiving carbamazepine/dipyridamole), if no response within 1-2 min increase to 12mg, repeat if needed max 12mg Child < 50 kg: Initially 0.05-0.1mg/kg, max 6mg, if no response within 1-2 min increase to 0.05-0.1mg/kg repeat if needed, max 0.3mg/kg or 12mg; >50 kg: Same as adult doseRapid bolus over 1-2 secs via peripheral vein | PSVT IN HEART TRANSPLANTATION PATIENTS IV Adult 3mg

Contra: Hypersensitivity, second/third-degree AV block, sinus node disease/symptomatic bradycardia, WPWS

Precautions: Asthma, angina, elderly, children

ADR: Serious: First/second-degree AV block, atrial tachyarrhythmias, hypotension, blurred vision, chest pain, Others: light-headedness, dizziness, apprehension, headache, nausea, dyspnea, burning sensation, facial flushing, sweating, metallic taste

DDI: Serious Nicotinic Acid increases HR, DBP & chest pain Others Theophylline/Caffeine reduces drug effect

Diet: Avoid dietary caffeine

Monitor: ECG, HR, BP

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