Amifostine

Details About Generic Salt ::  Amifostine 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Cytoprotectives

18B. CYTOPROTECTIVES in 18. ANTI-NEOPLASTIC AGENTS
AMIFOSTINE
ORGANIC THIOPHOSPHATE CYTOPROTECTIVE | CYTOPROTECTANT
also comes under 21A. Toxicity and Poison Management (Antidotes) in 21. Toxicity and Poison Management (Antidotes)
PK: D: 3.5L(vd) M: Hepatic(88%) E: Urine

Indications & Dose: CISPLATIN INDUCED RENAL TOXICITY Prophylactic therapy IV Adult 740mg/m2 (if cisplatin dose <100 mg/m2) | CYTOPROTECTIVE Chemotherapy IV Adult 910mg/m2 as inf for 15 min OD before chemotherapy, then reduce to 740mg/m2 in patients unable to tolerate dose | XEROSTOMIA Prophylactic therapy IV General 200mg/m2 OD 3min (start 15-30 min before radiotherapy)Patient undergoing radiation therapy for head & neck cancer

Contra: Hypersensitivity, hypotension/dehydration

Precautions: Antihypertensive therapy

ADR: Serious: hypotension, TEN, apnea, arrhythmia, anaphylactoid reactions, cardiac arrest, chest pain, MI, myocardial ischemia, respiratory arrest, SJS, tachycardia, urticaria, Others: hypocalcemia, vomiting, flushing, chills, somnolence, hiccups, sneezing, nausea

DDI: Serious Eplerenone increase risk of hypotensive/ Postural hypotension

Monitor: Arterial BP

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