Cefixime

Details About Generic Salt ::  Cefixime 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Cephalosporins

13B. CEPHALOSPORINS in 13. ANTI-INFECTIVES
CEFIXIME
THIRD GENERATION CEPHALOSPORIN | ANTI-INFECTIVE
PK: D: Extensive E: Urine (50% of absorbed dose as active drug) & feces (10%)

Indications & Dose: BRONCHITIS Acute PO Adult 400mg OD/200mg BID Child 6 months-12 yr: 8mg/kg/day in one or two divided doses, >12 yr (>50kg): Same as adult dose | DISSEMINATED GONOCOCCAL INFECT PO Adult Suspension: 400mg BID for 1 wk followed by initial parenteral regimen | EXACERBATION OF CHRONIC BRONCHITIS Acute PO Adult 400mg OD/200mg BID Child 6 months-12 yr: 8mg/kg/day in one or two divided doses, >12 yr (>50kg): Same as adult dose | GONORRHEA Uncomplicated PO Adult 400mg single dose Child >8 yr (>45kg): 400mg single dose | LYME DISEASE PO Adult 200mg/day for 100 days with probenecid 500mg TID | OTITIS MEDIA Acute PO Adult 400mg OD/200mg BID Child 6 months-12 yr: 8mg/kg/day in one or two divided doses, >12 yr (>50kg): Same as adult dose | PHARYNGITIS/TONSILLITIS PO Adult 400mg OD/200mg BID Child 6 months-12 yr: 8mg/kg/day in one or two divided doses, >12 yr (>50kg): Same as adult dose | SHIGELLOSIS PO Child 8mg/kg/day 5 days | TYPHOID FEVER PO Child 6 months-16 yr: 5-10mg/kg/day in 2 divided doses 2 wks | URINARY TRACT INFECT PO Adult 400mg OD/200mg BID Child 6 months-12 yr: 8mg/kg/day in one or two divided doses, >12 yr (>50kg): Same as adult dose

Contra: Hypersensitivity to cephalosporins

Precautions: Sensitivity to ß-Lactam antibacterials, moderate renal impairment, use may result in false positive urinary glucose, false positive Coombs’ test

ADR: Serious: allergic reactions, anaphylaxis, erythema multiforme, TEN, transient hepatitis, cholestatic jaundice, eosinophilia, blood disorders, reversible interstitial nephritis, Others: hyperactivity, nervousness, sleep disturbances, hallucinations, confusion, hypertonia, dizziness, diarrhea, nausea, vomiting, abdominal discomfort, headache

DDI: Serious Nifedipine increases drug levels

Diet: With food

Monitor: LFTs, renal function test periodically, signs & symptoms of anaphylaxis during first dose