Details About Generic Salt ::  Oxacilli

Main Medicine Class:: Antibiotic, Penicillin   

(ox-uh-SILL-in SO-dee-uhm)
Oxacillin Sodium
Powder for oral solution: 250 mg/5 mL
Powder for injection: 500 mg
Powder for injection: 1 g
Powder for injection: 2 g
Powder for injection: 10 g
Class: Antibiotic, Penicillin


Drugs Class ::

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Indications for Drugs ::

 Indications Treatment of infections caused by penicillinase-producing staphylococci; initial therapy of suspected staphylococcal infection.

Drug Dose ::


Adults: PO/IV/IM 250 mg to 1 g q 4 to 6 hr. Children (less than 40 kg): PO/IV/IM 50 to 100 mg/kg/day in divided doses q 4 to 6 hr. Premature/Neonates: IV/IM 25 mg/kg/day.

Contraindication ::

 Contraindications Hypersensitivity to penicillins. Do not treat severe pneumonia, empyema, bacteremia, pericarditis, meningitis and purulent or septic arthritis with oral oxacillin during acute state.

Drug Precautions ::


Pregnancy: Category B. Lactation: Excreted in breast milk. Hypersensitivity: Reactions range from mild to life-threatening. Administer cautiously to cephalosporin-sensitive or imipenem-sensitive patients because of possible crossreactivity. Pseudomembranous colitis: Consider pseudomembranous colitis in patients who develop diarrhea. Sodium content: Contains 2.5 to 3.1 mEq sodium/g. Superinfection: May result in bacterial or fungal overgrowth of nonsusceptible organisms.


Drug Side Effects ::

 Adverse Reactions

CNS: Neurotoxicity (eg, lethargy, neuromuscular irritability, hallucinations, convulsions and seizures); dizziness; fatigue; insomnia; reversible hyperactivity; prolonged muscle relaxation. DERMATOLOGIC: Ecchymosis. EENT: Itchy eyes; abnormal taste perception. GI: Glossitis; stomatitis; gastritis; sore mouth or tongue; dry mouth; furry tongue; black “hairy” tongue; nausea; anorexia; vomiting; abdominal pain or cramp; diarrhea or bloody diarrhea; rectal bleeding; flatulence; enterocolitis; pseudomembranous colitis; anorexia. GU: Interstitial nephritis (eg, oliguria, proteinuria, hematuria, hyaline casts, pyuria); nephropathy; increased creatinine and BUN; vaginitis. HEMATOLOGIC: Deep vein thrombosis; hematomas; phlebitis; anemias; thrombocytopenia; eosinophilia; leukopenia; granulocytopenia; neutropenia; bone marrow depression; agranulocytosis; reduced Hgb or Hct; prolongation of bleeding and prothrombin time. HEPATIC: Transient hepatitis; cholestatic jaundice; increased LFT results. METABOLIC: Elevated serum alkaline phosphatase, AST, ALT, bilirubin, and LDH; hypernatremia; hypokalemia; reduced albumin, total proteins, and uric acid. OTHER: Hypersensitivity reactions that may lead to death; hyperthermia; pain at site of injection; hyperthermia; sciatic neuritis.

Drug Mode of Action ::  

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Drug Interactions ::


Contraceptives, oral: Reduced efficacy of oral contraceptives. Probenecid: Increased oxacillin levels. Tetracyclines: Impaired bactericidal effects of oxacillin. Aminoglycosides.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies.
  • Ensure that specimens for culture and sensitivity have been obtained before starting therapy.
  • Assess for infection at beginning and throughout course of therapy (eg, fever, appearance of wound, increased WBC).
  • Observe patient for signs and symptoms of anaphylaxis (eg, rash, pruritis, laryngeal edema, wheezing). Discontinue drug if these symptoms occur.
  • Keep resuscitation equipment, adrenaline, and antihistamines available.
  • Notify health care provider if unusual bleeding or bruising occurs.
  Neuromuscular hyperexcitability, stupor, agitation, confusion, asterixis, hallucinations, coma, multifocal myoclonus, seizures, encephalopathy

Drug Storage/Management ::


  • Administer at regular intervals around the clock.
  • Administer oral doses on empty stomach at least 1 hr before or 2 hr after meals.
  • Reconstitute IM preparation to dilution of 250 mg/1.5 mL. Use deep, slow injection. Rotate sites to prevent tissue irritation.
  • Reconstitute IV preparation with Sterile Water for Injection or Sodium Chloride for Injection. Administer slowly over approximately 10 min to prevent vein irritation.
  • IM solution is stable for up to 3 days at room temperature or 7 days under refrigeration.
  • IV solutions are stable for at least 6 hr at room temperature.
  • Reconstituted oral solution is stable for 14 days if refrigerated.

Drug Notes ::

 Patient/Family Education

  • Advise patient to complete full course of therapy, even if symptoms abate, to prevent reoccurrence of infection.
  • Instruct patient to discard any liquid forms of medication after 7 days if stored at room temperature; after 14 days if refrigerated.
  • Instruct patient to notify health care provider if symptoms of infection do not improve.
  • Advise patient to report puritus and rash immediately.
  • Instruct patient to report the following signs of superinfection: black, “furry” tongue, loose or foul-smelling stools, vaginal itching, discharge.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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