Details About Generic Salt ::  Isosorbide Dinitrate 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

also comes under 4A. Drugs for Cardiac Failure & Shock in 4. Cardiovascular System
PK: A: Rapid D: 2-4 L/kg (Vd) M: Hepatic E: Urine & feces

Indications & Dose: ANGINA PO Adult 20-120mg/day in divided doses based on patient’s need max 240mg/day in divided doses, SR: 5-40mg QID or 40mg BID/TID | SL Adult 2.5-5mg q5-10min, max 3 doses in 15-30min, also use prophylactically 15min prior to activities which may provoke an attack | CONGESTIVE HEART FAILURE PO Adult Initially 20mg TID/QID, target dose 120-160mg/day in divided doses with hydralazine (37.5mg) | CORONARY SPASM Adult Intracoronary: Given as bolus 1mg prior to balloon inflation, max 5mg within 30min during PTCAGiven by intracoronary route to allow prolonged balloon inflation & to prevent/relieve coronary spasm | HEART FAILURE PO Adult 30-160mg/day in divided doses may increase to 240mg/day | SL Adult 5-10mg q2-3h | UNSTABLE ANGINA IV Adult Inf: 2-12mg/h but up to 20 mg/h may be necessary in some patients

Contra: Hypersensitivity, concurrent use with PDE-5 inhibitors, severe hypotension, hypovolemia, marked anemia, HF due to obstruction, raised intracranial pressure due to head trauma/cerebral hemorrhage, angle-closure glaucoma

Precautions: Head trauma, elderly, hypothermia, malnutrition, hypothyroidism, severe renal/hepatic impairment, metalcontaining TD patches should be removed before cardioversion/diathermy

ADR: Serious: Syncope, postural hypotension, hypotension, flushing, tachycardia, tachycardia, impairment of respiration, vomiting/restlessness/blurred vision, bradycardia, Others: contact dermatitis, local irritation & erythema, dizziness, Headache

DDI: Serious Phosphodiesterase type-5 inhibitors potentiate hypotensive effects of drug

Monitor: BP, HR


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