Etanercept

Details About Generic Salt ::  Etanercept 

Main Medicine Class:: Musculoskeletal Disorders , Pain   Sub Medicine Class ::  Anti Rheumatic Drugs (DMARDs)

12D. ANTI-RHEUMATIC DRUGS (DMARDS) in 12. MUSCULOSKELETAL DISORDERS & PAIN
ETANERCEPT
IMMUNOMODULATOR (TNF BLOCKER) | ANTI-RHEUMATIC
also comes under 15I. Anti-Psoriatic Drugs in 15. Skin
PK: A: Slow (SC) D: 17L M: Proteolysis E: Bile & urine

Indications & Dose: PLAQUE PSORIASIS PO Adult Initially 25-50mg twice weekly at intervals of 3 or 4 days 12 wk, then reduce dose to 25mg twice weekly or 50mg weekly. Continue until remission is achieved (24 wk) & if no response after 12 wk then discontinueIn patients whom other systemic treatments are not suitable | POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS Active disease/Severe SC Child >2 yr: 800µg/kg weekly, as 2 separate inj given on same day or 3-4 days apart | RHEUMATOID ARTHRITIS/PSORIATIC ARTHRITIS/ANKYLOSING SPONDYLITIS SC Adult 25mg twice weekly at intervals of 3-4 days. The equivalent weekly dose of 50mg given as single 50mg inj or as 2 separate 25mg inj

Contra: Hypersensitivity, patients with sepsis, wegener’s granulomatosis

Precautions: HF/reduced ventricular function, chronic infect/history of recurrent infect, CNS demyelinating disorders, patients with hematological disorders, moderate-to-severe alcoholic hepatitis

ADR: Serious: SJS, vasculitis, GI hemorrhage, HF, infect, reactivation of latent TB infect, lymphadenopathy, lymphomas, malignancies, Others: erythema, itching, pain, headache, dizziness, nausea, vomiting, dyspepsia, allergic reactions

DDI: Serious Isoniazid causes optic neuritis, Sulfasalazine decreases neutrophil count, Cyclophosphamide increases incidence of malignancies (Wegener’s granulomatosis patients)

Monitor: Signs & symptoms of infection, latent TB screening before therapy

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