Milrinone

Details About Generic Salt ::  Milrinone 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Drugs for Cardiac Failure , Shock

4A. DRUGS FOR CARDIAC FAILURE & SHOCK in 4. CARDIOVASCULAR SYSTEM
MILRINONE
PDE INHIBITOR | POSITIVE INOTROPIC & VASODILATOR
PK: A: Rapid & complete D: 0.32-0.45 L/kg(Vd) M: Hepatic E: Urine

Indications & Dose: ADVANCED CARDIOVASCULAR LIFE SUPPORT IV Adult Inj: Loading dose 50µg/kg over 10min, then 0.375-0.75µg/kg/min as inf for 2-3 days, may adjust dose to support BP, cardiac index & systemic perfusionwith catecholamines | CONGESTIVE HEART FAILURE Short-term therapy IV Adult Inj: Initially 50µg/kg over 10 min MD 0.375-0.75µg/kg/min by continuous inf, max 1.13mg/kg/day, may adjust inf according to cardiac output & pulmonary capillary wedge pressure

Contra: Hypersensitivity, acute MI

Precautions: Atrial flutter/fibrillation, renal impairment, electrolyte abnormalities, hypertrophic cardiomyopathy, severe obstructive aortic/pulmonary valvular disease

ADR: Serious: Supraventricular & ventricular arrhythmias, hypotension, angina-like chest pain, thrombocytopenia, tremor, Others: hypokalemia, headache

DDI: Serious Anagrelide increases inotropic effects

Diet:

Monitor: Platelet count, CBC, electrolytes, LFT, renal function test, ECG, CVP, SBP, DBP, HR

Related Posts:
You May Also Like::