Indications & Dose: PARTIAL SEIZURES WITH/ WITHOUT SECONDARY GENERALIZATION PO Adult Initially 300mg BID, increase according to response in steps of up to 600mg/day q1wk, usual dose 0.6–2.4g/day in divided doses Child 6–18 yr: 8–10mg/kg/day in 2 divided doses, increase according to response in steps of up to 10mg/kg/day q1wk, max 46mg/kg/day in divided doses

Precautions: avoid abrupt withdrawal, hyponatremia, cardiac conduction disorders, acute porphyria, hepatic/renal impairment

ADR: Serious: SJS, TEN, hepatitis, hyponatremia, pancreatitis, arrhythmias, thrombocytopenia, tremor, Others: diplopia, alopecia, nystagmus, leucopenia, diarrhea, nausea, vomiting, constipation, headache, dizziness, drowsiness, asthenia, ataxia, confusion, urticaria

DDI: Serious Furosemide causes hyponatremia, Phenytoin level is increased, Pregabalin level is reduced, Lamotrigine levels are modestly reduced, Lithium may increase the risk of neurotoxicity, Felodipine serum level is reduced, Combined hormonal contraceptives steroid levels are reduced

Diet: With/without food

Monitor: Seizure frequency, serum sodium, suicidality