Indications & Dose: ACUTE IRON TOXICITY IV Adult Initially 1g followed by 500mg q4h for 2 doses, subsequent doses of 500mg have been administered q4-12h based on clinical response, max 6g/day Child >3 yr: 15mg/kg/h, max 6g/dayThis route is preferred in a state of cardiovascular collapse only | IM Adult Initially 1g followed by 500mg q4h for 2 doses, subsequent doses of 500mg have been administered q4-12h based on clinical response, max 6g/day Child >3 yr: 90mg/kg/dose q8h, max 6g/day | CHRONIC IRON OVERLOAD IV Child >3 yr: 15mg/kg/h, max 6g/day | IM Adult Initially IM 0.5-1g/day, followed by 2g IV with each unit of blood transfused (administer separately from blood), max 6 g/day in transfusions received patients, 1g/day in absence of transfusions | SC Adult 1-2g/day or 20-40mg/kg/day over 8-24h Child >3 yr: 20-40mg/kg/day over 8-12h, max 1-2g/day

Precautions: Renal impairment

ADR: Serious: Hypotension, tachycardia, flushing, encephalopathy, hyperparathyroidism, growth retardation, hypocalcemia, angioedema, hepatic dysfunction, ARF, renal tubular disorders, acute respiratory distress syndrome, blurred vision, cataract, tinnitus, retinal pigment abnormalities, visual acuity decreased, optic neuritis, blood disorders, transaminases increased, night blindness, corneal opacities, arthralgia, seizure, Others: muscle spasms, diarrhea, nausea, vomiting, abdominal pain, dizziness, fever, headache, rash, urticaria, metaphyseal dysplasia, dysuria, urine discoloration, Inj site reactions

DDI: Serious Prochlorperazine causes unconsciousness, Ascorbic Acid may causes cardiac disorders

Monitor: Serum iron, ferritin, total iron-binding capacity, CBC with differential, Se creatinine, LFTs, serum chemistries, ophthalmologic exam & audiometry with long-term treatment, growth & body weight in children (every 3 months)