Details About Generic Salt ::  Alfentan

Main Medicine Class:: Narcotic agonist analgesic   

(al-FEN-tuh-NILL HIGH-droe-KLOR-ide)
Class: Narcotic agonist analgesic


Drugs Class ::

 Action Binds opioid receptors in CNS.

Indications for Drugs ::

 Indications Induction of analgesia and anesthesia in specific situations, monitored anesthesia care (MAC).

Drug Dose ::


Obese Patients

Calculate dosage on basis of lean body weight.

Spontaneously Breathing/Assisted Ventilation

ADULTS: INITIAL DOSE: IV 8 to 20 mcg/kg; maintenance: 0.5 to 1 mcg/kg/min.

Incremental Injection

ADULTS: INITIAL DOSE: IV 20 to 50 mcg/kg; maintenance: 5 to 15 mcg/kg every 5 to 20 min.

Anesthetic Induction

ADULTS: INITIAL DOSE: IV 130 to 245 mcg/kg; maintenance: IV 0.5 to 1.5 mcg/kg/min (or use general anesthetic).

Continuous Infusion

ADULTS: INITIAL DOSE: IV 50 to 75 mcg/kg; maintenance: 0.5 to 3 mcg/kg/min.


ADULTS: Initial dose: IV 3 to 8 mcg/kg; maintenance: 3 to 5 mcg/kg every 5 to 20 min to 1 mcg/kg/min; total dose: 3 to 40 mcg/kg.

Contraindication ::

 Contraindications Hypersensitivity to narcotics; diarrhea caused by poisoning until toxic agent is identified; acute bronchial asthma; upper airway obstruction.

Drug Precautions ::


Pregnancy: Category C. Lactation: Undetermined. Labor: Narcotics cross placenta and can affect neonate. Children: Hypotension has occurred in neonates receiving alfentanil. Not recommended for children < 12 yr. Elderly patients: Decreased dosage may be necessary. Cardiac effects: Drug may cause bradycardia and hypotension; may aggravate arrhythmias. CNS depression: Patient may be sensitive to depressive effects of alfentanil. Head injury: Alfentanil may increase intracranial pressure. Respiratory effects: Alfentanil may decrease respiratory drive and cause apnea. Seizures: Alfentanil may cause or aggravate seizure disorder. Skeletal muscle rigidity: Alfentanil may cause skeletal muscle rigidity, particularly of the truncal muscle.


Drug Side Effects ::

 Adverse Reactions

CV: Hypotension; hypertension; tachycardia; bradycardia; asystole hypercarbia; arrhythmia. CNS: Sedation; dizziness. EENT: Blurred vision. GI: Nausea; vomiting. RESP: Respiratory depression; bronchospasm; apnea. OTHER: Muscular rigidity.

Drug Mode of Action ::  

 Action Binds opioid receptors in CNS.

Drug Interactions ::


Cimetidine: Reduces alfentanil clearance. CNS depressants: May increase CNS and cardiovascular effects of alfentanil. Diazepam: May produce cardiovascular depression when given with high doses of alfentanil. Erythromycin: May increase levels of alfentanil, causing prolonged or delayed respiratory depression. Protease inhibitors: May increase CNS and respiratory depression.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies.
  • Monitor vital signs frequently during and after administration.
  • Monitor serum amylase or lipase concentrations for elevations.
  • Assist patient with ambulation.
  Respiratory depression, CNS depression, circulatory collapse (usually after rapid IV administration).

Drug Storage/Management ::


  • Drug is to be administered only by those qualified to give IV anesthetics.
  • For accurate administration of small volumes, use tuberculin syringe or equivalent.
  • Slow IV administration (90 sec to 3 min) reduces incidence of adverse reactions.
  • Infusion should be discontinued 10 to 15 min before surgery is complete.

Drug Notes ::

 Patient/Family Education

  • Instruct preoperative patient about possible side effects.
  • Advise postoperative patient to rise from bed slowly and to call for assistance in ambulation.
  • Instruct patient to avoid intake of alcoholic beverages or other CNS depressants for 24 hr after outpatient surgery.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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