Details About Generic Salt ::  Aminosal

Main Medicine Class:: Anti-infective,antitubercular   

(uh-MEE-no-suh-LIS-ih-late SO-dee-uhm)
Paser, Sodium P.A.S.  Nemasol Sodium-ICN
Class: Anti-infective/antitubercular

 

Drugs Class ::

 Action Competitively antagonizes metabolism of para-aminobenzoic acid, resulting in bacteriostatic activity against Mycobacterium tuberculosis.

Indications for Drugs ::

 Indications Treatment of tuberculosis (in combination with other antituberculous drugs) caused by susceptible strains of tubercle bacilli.

Drug Dose ::

 Route/Dosage

ADULTS: PO 12 to 16 g/day in 2 to 3 divided doses. CHILDREN: PO 275 to 420 mg/kg/day in 3 to 4 divided doses.

Contraindication ::

 Contraindications Severe hypersensitivity to aminosalicylate sodium and its congeners.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Excreted in breast milk. CHF: Use with caution because of high sodium content (55 mg of sodium per 500 mg tablet). Crystalluria: Maintain urine at neutral or alkaline pH to avoid crystalluria. Gastric ulcer: Use with caution. Hepatic or renal function impairment: Use with caution. Hypersensitivity: Stop medication if hypersensitivity symptoms develop. Restart cautiously.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

GI: Nausea; vomiting; diarrhea; abdominal pain. META: Goiter with or without myxedema. OTHER: Hypersensitivity (eg, fever, skin eruptions, infectious mononucleosis–like syndrome, leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, jaundice, hepatitis, encephalopathy, Loffler syndrome, vasculitis).

Drug Mode of Action ::  

 Action Competitively antagonizes metabolism of para-aminobenzoic acid, resulting in bacteriostatic activity against Mycobacterium tuberculosis.

Drug Interactions ::

 Interactions

Digoxin: May reduce oral absorption and serum levels of digoxin. Rifampin: May decrease absorption of rifampin. Vitamin B12: May decrease GI absorption of oral vitamin B12.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Review results of renal and hepatic function tests, and assess patient for undesirable side effects and adverse reactions. Notify physician of any unfavorable response.
  • Check patient record for notation of prescription for parenteral administration of vitamin B12 when aminosalicylate sodium will be given for more than a few wk or if patient is malnourished.
  • Do not discontinue without consulting physician.
  • Monitor urine pH and report any change toward acidity or crystal formation.
  • If patient is taking digoxin, monitor for signs of reduced serum levels of digoxin and notify physician of any associated signs, symptoms, or lab data.

Drug Storage/Management ::

 Administration/Storage

  • Administer with food or meals. Product may cause GI upset.
  • Sprinkle granules on acidic food or drink.
  • Do not leave medication in extreme heat or direct sunlight. Moisture, extreme heat, or direct sunlight may reduce effectiveness of product.
  • Do not use products that are brown or purple in color.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to take medication with meals or immediately after meals to minimize GI symptoms, and to maintain adequate fluid intake.
  • Explain to patient taking digoxin that dose may be increased while taking aminosalicylate sodium.
  • Instruct patient to report the following symptoms to physician: fever, sore throat, unusual bleeding or bruising, or skin rash.
  • Teach patient importance of maintaining urine at neutral or alkaline pH and demonstrate method for testing urine pH.
  • Instruct patient not to take otc medications without consulting physician.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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