Details About Generic Salt ::  Cefdinir

Main Medicine Class::    

(SEFF-dih-ner)
Omnicef
Class: Antibiotic/cephalosporin

 

Drugs Class ::

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Indications for Drugs ::

 Indications Treatment of community-acquired pneumonia, acute exacerbations of chronic bronchitis, acute maxillary sinusitis, pharyngitis and tonsilitis, uncomplicated skin and skin structure infections, and otitis media (pediatric patients only) due to susceptible strains of specific microorganisms.

Drug Dose ::

 Route/Dosage

ADULTS & CHILDREN > 13 YR PO 600 mg for 10 days (5 to 10 for pharyngitis/tonsillitis). CHILDREN 6 MO-12 YR PO 14 mg/kg (maximum of 600 mg).

Renal Impairment (CrCl < 30 ml/min)

ADULTS & CHILDREN > 13 YR PO 300 mg/day. CHILDREN 6 MO to 12 YR PO 7 mg/kg (maximum of 300 mg).

Contraindication ::

 Contraindications Hypersensitivity to cephalosporins.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Undetermined. Children: Saftey and efficacy in children < 6 mo not established. Hypersensitivity: Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients due to possible cross-reactivity. Pseudomembranous colitis: Should be considered possibility in patients in whom diarrhea develops. Renal impairment: Use drug with caution in patients with renal impairment. Dosage adjustment is recommended in patients with CrCl < 30 ml/min. Superinfection: May result in bacterial or fungal overgrowth of nonsusceptible microorganisms. Hemodialysis patients: A single dose of 300 mg or 7 mg/kg (maximum 300 mg) may be administered at the end of each dialysis session. Subsequent doses are then administered every other day.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CNS: Headache. DERM: Rash; cutaneous moniliasis. GI: Diarrhea; nausea; vomiting; abdominal pain. GU: Vaginitis. OTHER: Elevated liver enzymes; proteinuria; RBCs in urine; eosinophilia; elevated urine pH.

Drug Mode of Action ::  

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Drug Interactions ::

 Interactions

Aluminum- or magnesium-containing antacids: Concurrent administration reduced absorption of cefdinir (separate doses by 2 hr). Probenecid: Inhibition of renal excretion of cefdinir. Iron supplements and vitamins with iron: Concurrent administration reduces absorption of cefdinir (separate doses by 2 hr).

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history and drug history especially any known allergies to cephalosporins and penicillins.
  • Obtain specimens for culture and sensitivity.
  • Ensure adequate fluid intake.
  • Assess renal function and monitor during therapy. Patients with renal insufficiency must receive reduced dosages to prevent accumulation to toxic levels.
  • Monitor patient for signs of infection, fever, and clinical response to treatment (eg, breath sounds, heart sounds, appearance of stools and urine).
  • Review laboratory tests (including CBC, X-rays) as soon as possible.
  • Assess for signs of superinfections (eg, vaginitis, stomatitis, oral or vaginal white plaques, red raised rash, diarrhea).
  • Assess for diarrhea with blood or pus, which may be symptomatic of pseudomembranous colitis. Symptoms may occur after antibiotic treatment is stopped.
OVERDOSAGE: SIGNS & SYMPTOMS
  Seizures

Drug Storage/Management ::

 Administration/Storage

  • After mixing the suspension can be stored at room temperature or in the refrigerator. The containers should be kept tightly closed, and the suspension should be shaken well before each administration. Discard after 10 days.
  • Administer without regard to food.
  • Administer two hours before or after iron supplements or antacids.
  • Administer cautiously to penicillin-sensitive patients as cross-allergic reactions, although rare, can occur. Do not administer to patients with a history of severe reaction to penicillin.
  • Do not administer prior to hemodialysis, as dialysis removes cefdinir from the body. Follow recommended administration schedule for patients on dialysis.
  • Note dosage adjustments for patients with renal function impairment.
  • Store capsules at room temperature. Protect from moisture.

Drug Notes ::

 Patient/Family Education

  • Provide patient information pamphlet.
  • Instruct patient to complete full course of therapy.
  • If GI upset occurs, patient should take oral preparation with food.
  • Inform diabetic patients to use an enzyme-based test as medication can cause false positive test reaction for urine glucose.
  • Inform diabetic patients to use an enzyme-based test as medication can cause a false positive test reaction for urine glucose.
  • Instruct patient to take cefdinir 2 hours before or after iron supplements or antacids.
  • Remind patient to monitor body temperature daily. If fever persists for more than a few days, or if high fever (> 102° F) or shaking chills present, notify health care provider immediately.
  • Encourage patient to report any symptoms of nausea, vomiting, diarrhea, skin rash, sore throat, bruising, hives, muscle or joint pain to their primary care provider.
  • Instruct patient to report signs of superinfection, which often occurs with prolonged or multiple drug therapy. These include vaginal itching or discharge, white or gray patches in the mouth, furry tongue, red raised rash, or foul-smelling stools.
  • Warn the patient that diarrhea containing pus or blood may indicate a serious disorder and they should seek immediate treatment.
  • Teach patient to identify signs of hypersensitivity that might occur during the course of therapy (eg, urticaria, rash, hypotension, difficulty in breathing or wheezing). Patient should discontinue drug immediately and seek emergency therapy if wheezing or difficulty breathing occurs.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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