Details About Generic Salt ::  Desipram

Main Medicine Class:: Tricyclic antidepressant   

(dess-IPP-ruh-meen HIGH-droe-KLOR-ide)
Norpramin, Alti-Desipramine, Apo-Desipramine, Dom-Desipramine, Novo-Desipramine, Nu-Desipramine, PMS-Desipramine
Class: Tricyclic antidepressant

 

Drugs Class ::

 Action Inhibits reuptake of norepinephrine and serotonin in CNS.

Indications for Drugs ::

 Indications Relief of symptoms of depression. Unlabeled use(s): Facilitation of cocaine withdrawal; treatment of panic and eating disorders (eg, bulimia nervosa).

Drug Dose ::

 Route/Dosage

ADULTS: PO 100 to 300 mg/day. May be given in divided doses or once daily at bedtime. ELDERLY AND ADOLESCENT PATIENTS: PO 25 to 150 mg/day.

Contraindication ::

 Contraindications Hypersensitivity to any tricyclic antidepressant. Not to be given in combination with or within 14 days of treatment with an MAO (monoamine oxidase) inhibitor; cross-sensitivity may occur across the dibenzazepines. Do not give during acute recovery phases of MI.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Not recommended in children < 12 yr. Special risk patients: Use drug with caution in patients with history of seizures, urinary retention, urethral or ureteral spasm, angle-closure glaucoma, increased intraocular pressure, or cardiovascular disorders; in patients receiving thyroid medication and in patients who have hepatic or renal impairment, schizophrenia or paranoia.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Orthostatic hypotension; hypertension; tachycardia; palpitations; arrhythmias; ECG changes; hypertensive episodes during surgery; stroke; heartblock; CHF. CNS: Confusion; disturbed concentration; hallucinations; delusions; nervousness; numbness; tremors; extrapyramidal symptoms (pseudoparkinsonism; movement disorders; akathisia); restlessness; agitation; panic; insomnia; nightmares; mania; exacerbation of psychosis; drowsiness; dizziness; weakness; fatigue; emotional lability; seizures. DERM: Rash; pruritus; photosensitivity reaction; dry skin; acne; itching; sweating. EENT: Conjunctivitis; blurred vision; increased intraocular pressure; mydriasis; tinnitus; nasal congestion; peculiar taste in mouth. GI: Nausea; vomiting; anorexia; GI distress; diarrhea; flatulence; dry mouth; constipation. GU: Impotence; sexual dysfunction; nocturia; urinary frequency; urinary tract infection; vaginitis; cystitis; urinary retention or hesitancy. HEPA Hepatitis; jaundice. HEMA: Bone marrow depression including agranulocytosis; eosinophilia; purpura; thrombocytopenia; leukopenia. META: Elevation or depression of blood sugar levels. RESP: Pharyngitis, rhinitis; sinusitis; bronchospasm; cough. OTHER: Breast enlargement.

Drug Mode of Action ::  

 Action Inhibits reuptake of norepinephrine and serotonin in CNS.

Drug Interactions ::

 Interactions

Barbiturates, carbamazepine, charcoal: May decrease desipramine effects. Cimetidine, fluoxetine, haloperidol, quinidine, oral contraceptives, phenothiazine antipsychotics: May increase desipramine effects. Clonidine: May result in hypertensive crisis. CNS depressants: CNS and respiratory effects may be increased. MAO inhibitors: Hyperpyretic crises, severe convulsions and death may occur if administered together or within 14 days of each other.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Document serum bilirubin, alkaline phosphatase and blood glucose levels throughout therapy.
  • Assess and document baseline behaviors and psychological status.
  • Notify physician and discontinue medication immediately if patient has increased agitation and/or paranoid delusions.
  • Document body weight monthly.
  • Notify physician and withhold medication if there is a BP drop of 20 mmHg or if heart arrhythmia or increase in heart rate develops.
  • Inform physician if patient has urinary elimination problems.
OVERDOSAGE: SIGNS & SYMPTOMS
  Confusion, agitation, hallucinations, seizures, status epilepticus, clonus, choreoathetosis, hyperactive reflexes, positive Babinski’s signs, coma, cardiac arrhythmias, renal failure, flushing, dry mouth, dilated pupils, hyperpyrexia

Drug Storage/Management ::

 Administration/Storage

  • Administer in equal doses or one dose at bedtime.

Drug Notes ::

 Patient/Family Education

  • Warn patient of risk of seizure.
  • Instruct patient to keep weekly record of weight.
  • Teach patient how to take BP and heart rate.
  • Explain missed medication procedure: < 2 hrs, take medication; more than 2 hrs, wait until next scheduled dose. Do not double doses.
  • Teach proper techniques for oral hygiene to help prevent/treat dry mucous membranes.
  • Tell patient to increase fluid intake.
  • Inform male patient of possible sexual dysfunction.
  • Tell patient of possible difficult urination.
  • Instruct patient to avoid intake of alcoholic beverages or other CNS depressants.
  • Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.
  • Advise patient to complete full course of therapy; may take 4 to 6 wks to see full benefits.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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