Details About Generic Salt ::  Rapacuro

Main Medicine Class:: Muscle relaxant,nondepolarizing neuromuscular blocker   

(rah-pah-cure-OH-nee-uhm BROE-mide)
Raplon
Class: Muscle relaxant/nondepolarizing neuromuscular blocker

 

Drugs Class ::

 Action Binds competitively to cholinergic receptors on motor end-plate to antagonize action of acetylcholine, resulting in block of neuromuscular transmission.

Indications for Drugs ::

 Indications Adjunct to general anesthesia to facilitate tracheal intubation; provide skeletal muscle relaxation during surgery.

Drug Dose ::

 Route/Dosage

ADULTS: IV Initial dose: 1.5 mg/kg; maintenance dose: Up to three doses of 0.5 mg/kg. CESAREAN SECTION: 2.5 mg/kg with thiopental induction. CHILDREN 1 MO TO 12 YR: IV 2 mg/kg. CHILDREN 13 TO 17 YR: IV Determine dose by physical maturity, height, and weight using above dosing recommendations.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children < 1 mo: Safety and efficacy not established; has not been studied in patients 13 to 17 yr. Hepatic insufficiency: Use with caution, resistance to neuromuscular blockade and prolonged duration of blockade may occur. Obesity: Base initial dose in obese patients (body mass index ³ 30) on actual body weight; consider dosing morbidly obese patients (body mass index ³40) on ideal body weight. Renal failure: Onset time may be slowed and duration of blockade may be prolonged.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV Hypotension; tachycardia; bradycardia; extrasystoles; arrhythmias; cardiac failure; MI. RESP: Bronchospasm. GI: Vomiting; nausea. DERM: Erythematous rash.

Drug Mode of Action ::  

 Action Binds competitively to cholinergic receptors on motor end-plate to antagonize action of acetylcholine, resulting in block of neuromuscular transmission.

Drug Interactions ::

 Interactions

Antibiotics (eg, aminoglycosides, bacitracin, colistin, polymyxin, tetracyclines, vancomycin), inhalational anesthetics, lithium, local anesthetics, magnesium salts, procainamide, quinidine: Prolonged neuromuscular blockade may occur. Anticonvulsants (eg, carbamazepine, phenytoin): Shortened duration of action and decreased effectiveness. Incompatibilities: Cefuroxime, danaparoid, diazepam, nitroglycerin, thiopental.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history including drug history and any known allergies.
  • Monitor the patient, including drug history and any known allergies.
  • Monitor vital signs and keep airway clear of secretions.
  • Use nerve stimulator to assess neuromuscular blockade.
  • Continually monitor patient’s hemodynamic status including bradycardia, tachycardia, hypotension, and hypertension.
  • Monitor for ECG abnormalities and tachyphylaxis following repeated and large single doses.
  • Ensure that a peripheral nerve simulator is available and used to monitor patient’s responses to drug and recovery from neuromuscular block.
  • Monitor for possible occurrence (rare) of malignant hyperthermia.
  • Maintain patent airway, adequate oxygenation, and controlled ventilation in the case the neuromuscular block and subsequent respiratory depression extends beyond the time needed for surgery and anesthesia.
  • Closely monitor patients with hepatic, respiratory, cardiac, muscular, and renal disease.
  • Monitor patients with myasthenia gravis or Eaton-Lambert syndrome for potential profound and prolonged effects.
OVERDOSAGE: SIGNS & SYMPTOMS
  Flaccid paralysis, apnea, hypotension

Drug Storage/Management ::

 Administration/Storage

  • Store at 2° to 25°C (36° to 77°F).
  • When reconstituted with sterile water, keep vial at room temperature or refrigerate at 2° to 25°C (36° to 77°F) and use within 24 hrs. For single use only, discard unused portion. Do not use if particulate matter is present.
  • When reconstituted with bacteriostatic water, store at room temperature or refrigerate at 2° to 25°C (36° to 77°F) and use within 24 hrs.
  • Do not administer to newborn infants if reconstituted with bacteriostatic water as it contains benzyl alcohol.
  • Administer IV only in carefully adjusted doses individualized to patient needs by or under the supervision of experienced clinicians who are familiar with the drug actions and possible complications.
  • Do not administer unless personnel and facilities for resuscitation and life support (tracheal intubation, artificial ventilation, oxygen therapy) and an antagonist (anticholinesterase [eg, neostigmine]) of the drug are available, and a peripheral nerve simulator to measure neuromuscular function are immediately available.
  • Administration must be accompanied by adequate anesthesia or sedating agents.

Drug Notes ::

 Patient/Family Education

  • Explain that drug will be administered while patient is unconscious.
  • Inform family of the usual length and nature of the unit’s routine as they are often in the waiting room.
  • Inform family of patient’s condition during the procedure and in the recovery room.
  • Inform patient and family that hoarseness and sore throat may be experienced.
  • Report any residual muscle weakness to primary caregiver.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

DOWNLOAD OUR ANDROID APP

One of the 1st in India.High Quality Generic Medicine Portal Android Application for Online Oreder & Information.

For More Join Our Membership and Get Additional 25% off on Meds, also get MLM Benefits to get a permanent earning source.

Join Membership How to Search Medicine
Android App

We would like to keep you updated with special notifications.