Article Contents ::
Details About Generic Salt :: Hyoscine
Main Medicine Class:: Gastrointestinal System Sub Medicine Class :: Anti Emetics
| 7G. ANTI-SPASMODICS in 7. GASTROINTESTINAL SYSTEM |
| HYOSCINE |
| CHOLINERGIC ANTAGONIST | ANTI-EMETIC, ANTI-SPASMODIC |
| also comes under 7D. Anti-Emetics in 7. Gastrointestinal System, |
| PK: A: Rapid D: Extensive M: Hepatic E: Fecees, urine |
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Indications & Dose: ANTIEMETIC SC Adult 0.6-1mg (as hydrobromide) Child 0.006mg/kg (as hydrobromide) | BILIARY & RENAL COLIC Symptomatic therapy IM Adult Inj: 20mg is given slowly, may be repeated after 30min, max 100mg/day (as butylbromide) | GASTROINTESTINAL ANTISPASMODIC PO Adult 20mg QID (as butylbromide) Child 6-12 yr: 10mg TID (as butylbromide) | IV/IM Adult Inj: 20mg inject slowly, may be repeat after 30mins if needed, max 100mg | IRRITABLE BOWEL SYNDROME PO Adult Initially 10mg TID, may be increase to 20mg QID (as butylbromide) | PREVENTION OF MOTION SICKNESS PO Adult 300µg taken 30min before journey, then 300µg q6h if needed, max 3 doses/day (as hydrobromide) Child 3-4 yr: 75µg, 4-10 yr: 75-150µg, >10 yr: 150-300µg 20 min before journey, may be repeat if needed, max 150µg/day (as hydrobromide) | PREVENTION OF POSTOPERATIVE NAUSEA & VOMITING IM/SC Adult 0.3-0.65mg (as hydrobromide) Child 6 months-3 yr: 0.1-0.15mg, 3-6 yr: 0.2-0.3mg (as hydrobromide) |
| Contra: Hypersensitivity, angle-closure glaucoma, pyloric obstruction/urinary bladder neck obstruction, prostatic hypertrophy, acute hemorrhage, thyrotoxicosis, paralytic ileus, renal/hepatic impairment, ulcerative colitis/toxic megacolon, tachycardia
Precautions: History of seizures/psychosis, elder, hepatic/renal dysfunction, patients with cardiac disease, autonomic neuropathy ADR: Serious: Blurred vision, mydriasis, cyclopegia, conjunctivitis, photophobia, toxic psychosis, arrhythmias, hallucinations, Others: Drowsiness, dizziness, confusion, restlessness, fatigue, constipation, dry mouth, urinary hesitancy/retention, rash, delirium, excitement, porphyria, decreased bronchial secretions, transient difficulty in micturition, reduction in tone & GIT motility DDI: Serious CNS Depressants/Alcohol enhances CNS sedative effects of drug Monitor: HR, signs of urinary retention |