Article Contents ::
Details About Generic Salt :: Valganciclovir
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 13M. ANTI-VIRALS (NON RETROVIRAL) in 13. ANTI-INFECTIVES |
| VALGANCICLOVIR |
| SYNTHETIC GUANINE DERIVATIVE | ANTI-VIRAL |
| PK: A: Well absorbed D: 0.7 L/kg (Vdss) M: Hepatic E: Urine |
|
Indications & Dose: CYTOMEGALOVIRUS RETINITIS PO Adult Induction: 900mg BID 21 days | PO Adult Maintenance: 900mg OD | PREVENTION OF CYTOMEGALOVIRUS RETINITIS IN ORGAN TRANSPLANT RECIPIENTS PO General 900mg OD 10 days before transplantation & continue for 100 days (heart/kidney-pancreas transplant) or 200 days (kidney transplant) post-transplantation |
| Contra: Hypersensitivity
Precautions: renal impairment, nephrotoxic agents, elderly, liver transplant recipients, history of pre-existing bone marrow suppression, history of cytopenias, myelosuppressive drugs ADR: Serious: HTN, tremor, peripheral edema, blood disorders, renal impairment, nasopharyngitis, arthralgia, bone marrow depression, hypokalemia, seizures, URTI, retinal detachment, Others: dysuria, back pain, muscle cramps, dyspnea, UTI, abdominal pain, hyperglycemia, cough, agitation, dermatitis, confusion, nausea, vomiting, fever, headache, insomnia, constipation DDI: Serious Mycophenolate causes neutropenia, Tenofovir causes renal failure & nephrotoxicity, Zidovudine increases hematological toxicity, Trimethoprim increases risk of myelosuppression, Imipenem leads to generalized seizures, Didanosine level raised, Probenecid reduces renal excretion Diet: With food Monitor: Retinal exam, CBC, platelet counts, SeCr |
