Daptomycin

Details About Generic Salt ::  Daptomycin 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

13Q. PEPTIDES in 13. ANTI-INFECTIVES
DAPTOMYCIN
CYCLIC LIPOPEPTIDE | ANTI-INFECTIVE
PK: D: Vss: 0.1 L/kg, Critically ill patients: Vss: 0.23±0.14 L/kg E: Urine (78%), feces (6%)

Indications & Dose: BACTERAEMIA IV Adult 6mg/kg OD for 2-6 wks | SKIN AND SOFT-TISSUE INFECTIONS IV Adult 4mg/kg OD for 1-2 wks

Contra: Hypersensitivity

Precautions: Discontinue use immediately with signs/symptoms of eosinophilic pneumonia/hypersensitivity, patients taking other drugs associated with myopathy, on prolonged use, peripheral neuropathy, renal impairment

ADR: Serious: Anemia, chest pain, peripheral edema, hypertension, hypotension, hypokalemia, hyperkalemia, hyperphosphatemia, eosinophilia, increased INR, increased ALT, AST, increased creatine phosphokinase, limb pain, back pain, osteomyelitis, weakness, arthralgia, gram-negative organism infection, bacteremia, sepsis, fungal infection, renal failure, pharyngolaryngeal pain, pleural effusion, cough, pneumonia, dyspnea, Others: Diarrhea, vomiting, constipation, insomnia, headache, dizziness , anxiety, skin rash, pruritus, diaphoresis, erythema, nausea, abdominal pain, dyspepsia, loose stools, GI hemorrhage, injection site reaction

DDI: Others Fibrates increases risk of muscle toxicity, NSAIDs increases risks of renal impairment, Warfarin results in falsely elevated PT

Monitor: CPK, signs & symptoms of infection/ eosinophilic pneumonia, for muscle pain or weakness

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