Details About Generic Salt ::  Chlorphe

Main Medicine Class::    

(klor-fen-AIR-uh-meen MAL-ee-ate)
4 mg
2 mg/5 mL
4 mg
Tablets, chewable
2 mg
Chlor-Trimeton Allergy 8 Hour
Tablets, extended-release
8 mg
Chlor-Trimeton Allergy 12 Hour
Tablets, extended-release
12 mg
Efidac 24
Tablet, extended-release
16 mg
Chlor-Tripolon Repetabs
Class: Antihistamine, Alkylamine


Drugs Class ::

 Action Competitively antagonizes histamine at H1 receptor sites.

Indications for Drugs ::

 Indications Temporary relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose caused by hay fever (allergic) rhinitis or other respiratory allergies.

Drug Dose ::


Symptomatic Allergic Conditions Adults and Children over 12 yr: PO 4 mg q 4 to 6 hr (immediate-release form) or 8 to 12 mg at bedtime or q 8 to 12 hr (sustained-release form) (max, 24 mg/24 hr). Efidac: 16 mg q 24 hr (max, 16 mg/24 hr). SC/IM/IV: 5 to 20 mg as single dose (max, 40 mg/24 hr).

Children 6 to 12 yr: PO 2 mg q 4 to 6 hr (immediate-release form) or 8 mg at bedtime or during day as indicated (sustained-release form) (max, 12 mg/24 hr).

Children 2 to 6 yr: PO (only tablet or syrup; sustained-release not recommended) 1 mg q 4 to 6 hr (max, 4 mg/24 hr).

Allergic Reactions to Blood or Plasma Adults: SC/IM/IV 10 to 20 mg as single dose (max, 40 mg/24 hr).

Anaphylaxis Adults: IV 10 to 20 mg as single dose.

Contraindication ::

 Contraindications Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO therapy; use in newborn or premature infants and in nursing mothers.

Drug Precautions ::


Pregnancy: Category B. Do not use during third trimester. Lactation: Contraindicated in nursing mothers. Children: Overdosage may cause hallucinations, convulsions, and death. Antihistamines may diminish mental alertness. In young child, they may produce paradoxical excitation. Contraindicated in newborn or premature infants. Sustained-release form not recommended in children less than 6 yr. Elderly: Greater likelihood of dizziness, excessive sedation, syncope, toxic confusional states and hypotension in patients greater than 60 yr. Dosage reduction may be required. Special risk patients: Use drug with caution in patients with predisposition to urinary retention, history of bronchial asthma, increased IOP, hyperthyroidism, cardiovascular disease, or hypertension. Avoid in patients with sleep apnea. Hepatic impairment: Use drug with caution in patients with cirrhosis or other liver disease. Hypersensitivity reactions: May occur. Have epinephrine 1:1000 immediately available. Respiratory disease: Generally not recommended to treat lower respiratory tract symptoms including asthma.


Drug Side Effects ::

 Adverse Reactions

CARDIOVASCULAR: Orthostatic hypotension; palpitations; bradycardia; tachycardia; reflex tachycardia; extrasystoles; faintness. CNS: Drowsiness (often transient); sedation; dizziness; faintness; disturbed coordination; nervousness; restlessness. GI: Dry mouth; epigastric distress; anorexia; nausea; vomiting; diarrhea; constipation; change in bowel habits. GU: Urinary frequency or retention; dysuria. HEMATOLOGIC: Hemolytic anemia; thrombocytopenia; agranulocytosis. METABOLIC: Increased appetite; weight gain. RESPIRATORY: Thickening of bronchial secretions; chest tightness; wheezing; nasal stuffiness; dry nose and throat; sore throat; respiratory depression. OTHER: Hypersensitivity reactions; photosensitivity.

Drug Mode of Action ::  

 Action Competitively antagonizes histamine at H1 receptor sites.

Drug Interactions ::


Alcohol and CNS depressants: May cause additive CNS depressant effects.

MAO Inhibitors: May increase anticholinergic effects of chlorpheniramine.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies.
  • Note baseline vital signs and monitor throughout therapy.
  • Monitor I&O. Note any urinary retention or problems with voiding.
  • Notify health care provider if patient has history of asthma.
  • If signs of allergy or difficulty breathing occur, notify health care provider.
  • Monitor breath sounds and report abnormalities to health care provider.
  Diminished mental alertness, ataxia, hallucinations, convulsions, death

Drug Storage/Management ::


  • Administer with food or milk to decrease GI upset.
  • Instruct patient not to chew or crush sustained-release tablets; have patient swallow tablet whole.
  • Instruct patient to chew chewable tablets and not to swallow tablet whole.
  • Administer 10 mg/mL solution IV, IM, or SC.
  • Administer 100 mg/mL solution IM or SC only; do not administer IV.
  • Administer IV solution undiluted in 10 mg dose over at least 1 min.
  • Store at room temperature. Protect syrup and injectable forms from light.

Drug Notes ::

 Patient/Family Education

  • Caution patient to avoid intake of alcoholic beverages or other CNS depressants.
  • Instruct patient to notify health care provider if blurred vision occurs.
  • Advise patient to use good oral hygiene, to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
  • Advise patient that coadministration of MAO inhibitors may prolong and intensify effects of medication.
  • Instruct patient to maintain adequate fluid intake to avoid thickening of respiratory secretions.
  • Caution patient to avoid exposure to sunlight and to use sunscreen or wear protective clothing to avoid photosensitivity reaction.
  • Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.
  • Advise patient to carry Medi-Alert identification noting allergic condition.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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