Details About Generic Salt ::  Milrinon

Main Medicine Class:: Cardiovascular   

(MILL-rih-nohn LAK-tate)
Class: Cardiovascular


Drugs Class ::

 Action Has direct arterial vasodilator activity and positive inotropic effect; ncreases myocardial contractility.

Indications for Drugs ::

 Indications Short-term treatment of CHF.

Drug Dose ::


ADULTS: IV Loading dose: 50 mcg/kg over 10 min; adjust infusion rate according to hemodynamic and clinical response.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::


Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Cardiovascular effects: Do not use in patients with severe obstructive aortic or pulmonic valvular disease; may exacerbate hypertrophic subaortic stenosis; may cause supraventricular and ventricular arrhythmias; may shorten atrioventricular node conduction. Renal impairment: Use drug with caution; monitor renal function. Dosage reduction, based on creatinine clearance, may be needed.


Drug Side Effects ::

 Adverse Reactions

CV: Ventricular arrhythmia (eg, ventricular ectopic activity, nonsustained ventricular tachycardia, sustained ventricular tachycardia, ventricular fibrillation); supraventricular arrhythmia; hypotension; angina. CNS: Headaches; tremor. Thrombocytopenia. OTHER: Hypokalemia.

Drug Mode of Action ::  

 Action Has direct arterial vasodilator activity and positive inotropic effect; ncreases myocardial contractility.

Drug Interactions ::

 Interactions None well documented. INCOMPATIBILITIES: Precipitate forms if furosemide is injected into same IV line as milrinone; do not administer both in same IV line.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies.
  • Evaluate renal function and identify whether patient has severe obstructive aortic or pulmonic valvular disease.
  • Provide close cardiac and BP monitoring.
  • Be especially observant for supraventricular and ventricular arrhythmias and excessive decreases in BP and report to physician.
  • Carefully monitor fluid and electrolyte changes as well as renal function during therapy.
  • Observe IV site for signs of irritation. Rotate injection site every 48 hr.
  • Correct hypokalemia by potassium supplementation prior to and during use of drug.
  • Observe for other common side effects (headaches, hypokalemia, tremor and thrombocytopenia) and report to physician.

Drug Storage/Management ::


  • For short-term (up to 5 days) IV use only.
  • Prepare drug for IV infusion by diluting with 0.45% or 0.9% Sodium Chloride Injection D5W.
  • Use infusion pump for administration.
  • Adjust maintenance infusion rate on the basis of hemodynamic and clinical response (maximum rate is 0.75 mcg/kg/min or 1.13 mg/kg/day).
  • Store at room temperature and protect from light.

Drug Notes ::

 Patient/Family Education

  • Explain what medication does.
  • Inform patient that treatment with this drug usually does not exceed 5 days.
  • Instruct patient to report these symptoms to physician: headache or tremors.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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