Exenatide

Details About Generic Salt ::  Exenatide 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
EXENATIDE
GLP 1 RECEPTOR AGONIST | ANTI-DIABETIC
PK: D: Vd: 28.3L M: Systemic metabolism E: Urine

Indications & Dose: TYPE 2 DIABETES MELLITUS Adjunct therapy SC Adult Initially 5mcg BID in patients who do not have adequate glycemic control (with metformin/sulfonylurea/ thiazolidinedione, or dual therapy with metformin plus sulfonylurea/or thiazolidinedine). Dose may increase to 10mg BID after 1 month

Contra: Hypersensitivity, severe renal impairment, type 1 DM/diabetic ketoacidosis

Precautions: renal transplantation patients

ADR: Serious: Hypoglycemia, acute pancreatitis, Others: mild to moderate nausea, vomiting, diarrhea, nervousness, dizziness, headache, dyspepsia, asthenia, decreased appetite, GERD, hyperhidrosis, rashes, hypersensitivity

DDI: Others Somatropin/Corticosteroids/Thiazides decreases exenatide effects, VKAs/Sulfonylureas levels increases

Monitor: Se glucose, Hb A1c, renal function

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