Megestrol

Details About Generic Salt ::  Megestrol 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

8G. PROGESTINS AND ANTI-PROGESTINS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
MEGESTROL
HORMONE | ANTI-NEOPLASTIC, APPETITE STIMULANT
PK: A: Well absorbed M: Hepatic E: Urine & feces

Indications & Dose: ANOREXIA/CACHEXIA PO Adult 400-800mg/day in cancer/AIDS patients | BREAST CANCER PO Adult 40mg QID or 160mg OD | ENDOMETRIAL CARCINOMA PO Adult 40-320mg in divided doses

Contra: Hypersensitivity

Precautions: adrenal suppression, DM, thromboembolism

ADR: Serious: HTN, cardiomyopathy, chest pain, edema, HF, Cushing’s syndrome, hypercalcemia, seizure, amblyopia, albuminuria, blood disorders, hepatotoxicity, thromboembolic phenomena, vaginal bleeding/discharge, Others: weakness, dyspnea, diaphoresis, malaise, rash, alopecia, hyperglycemia, gynecomastia, amenorrhea, diarrhea, vomiting, nausea, xerostomia, impotence, UTI, headache, insomnia, fever, confusion, depression

DDI: Serious Etoposide/Cisplatin effects are abolished by drug, Warfarin half-life prolongs by drug, Aminoglutethimide markedly reduces drug plasma level

Monitor: Signs of thromboembolic events, BP, serum glucose

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