Toxic Hepatitis and Drug Induced Hepatitis Diagnosis and Treatment

Toxic Hepatitis and Drug Induced Hepatitis Diagnosis and Treatment

Toxic Hepatitis and DrugAcute Myocardial Infarction (AMI) CLINICAL PRESENTATION AND PHYSICAL FINDINGS. Read more ... » Induced Hepatitis

Acute liver injury —

  • Acute DILI is the most common form of liver damage caused by drugs.

Drug Induced Hepatitis DIAGNOSIS —

  • The diagnosis of DILI can be difficult. The relationship between exposure to the drug and hepatic toxicity is not always clear.
  • There is no specific serum biomarker or characteristic histologic feature that reliably identifies a drug as the cause of toxicity
  • Exposure must precede the onset of liver injury (although the latent period is highly variable)
  • Underlying liver diseaseAcute Myocardial Infarction (AMI) CLINICAL PRESENTATION AND PHYSICAL FINDINGS. Read more ... » should be sought Injury may improve when the drug is stopped (although in some cases injury may initially worsen for days or weeks while in fulminant cases, declining liver biochemical tests may indicate deterioration rather than improvement)
  • Liver injury may have recurred more rapidly and severely after repeated exposure.

Classification of liver test abnormalities

  • Hepatitis (hepatocellular) ALT 3 x ULN R 5
  • Cholestasis ALT 2 x ULN R 2
  • Mixed ALT 3 x ULN ALP 2 x ULN R >2 to <5

Types of drug-induced liver injury –

Acute liver injury  –Hepatocellular
Acarbose
Acetaminophen
Allopurinol
Aspirin
Buproprion
Bromfenac
Diclofenac
Ethanol
Fluoxetine
Halothane
IsoniazidTuberculosis Treatment Complete DRUGS - ATT (ANTITUBERCULAR TREATMENT)with MDR. Read more ... »
Ketoconazole
Lisinopril
Losartan
Methyl-dopa
Nefazodone
Nevirapine
Paroxetine
Phenytoin
PyrazinamideTuberculosis Treatment Complete DRUGS - ATT (ANTITUBERCULAR TREATMENT)with MDR. Read more ... »
Rifampin
Risperidone
Ritonavir
Sertraline
Statins
Tetracycline
Trazodone
Thiazolidinediones
Trovafloxacin
Valproate
Cholestasis
ACE inhibitorsHeart Failure Treatment Heart Failure GENERAL PRINCIPLES. Read more ... »
Amoxicillin/Clavulanate
Anabolic Steroids
Azathioprine
Chlorpromazine
Clopidogrel
Cytarabine
Erythromycins
Estrogens
Ethanol
Irbesartan
Phenothiazines
Sulindac
Terbinafine
Tricyclics
Mixed
Amitryptilline
Azathioprine
Captopril
Carbamazepine
Clindamycin
Cyproheptadine
Enalapril
Flutamide
Ibuprofen
Nitrofurantoin
Phenobarbital
Phenothiazines
Phenytoin
Sulfonamides
Trazodone
Sulfonamides
Verapamil
ChronicChronic Hepatitis Classification viral hepatitis Clinical features and Treatment. Read more ... » liver injury –Steatohepatitis
Amiodarone
Ethanol
Tamoxifen
Valproic Acid
Microvesicular steatosis
Ethanol
Methotrexate
NRTIs
Tetracycline
Valproic acid
Granulomatous hepatitis
Allopurinol
Carbamazepine
Diltiazem
Hydralazine
Penicillamine
Phenytoin
Procainamide
Quinidine
Rosiglitazone
Sulfonamides
Sinusoidal obstruction syndromeMetabolic,Insulin Resistance Syndrome X Causes Symptoms. Read more ... »
Busulfan
Cyclophosphamide
Imuran
Fibrosis
Ethanol
Methotrexate
Methyldopa
Peliosis hepatis
Anabolic steroids
Vinyl chloride
Autoimmune hepatitis
Nitrofurantoin
Minocycline
Statins
Chronic hepatitisChronic Hepatitis Classification viral hepatitis Clinical features and Treatment. Read more ... »
Diclofenac
Methyldopa
Minocycline
Nitrofurantoin
Trazodone
Neoplasm
Anabolic steroids
Oral contraceptivesPrimary Hypertension due to Endocrine adrenal Hypertension Adrenogenital syndrome Oral Contraceptives. Read more ... »
Vinyl chloride
Ischemic necrosis
Ergot

 

Extrahepatic manifestations —

Toxic Hepatitis and Drug Induced Hepatitis Treatment

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