Details About Generic Salt ::  Chloral

Main Medicine Class:: Sedative and hypnotic,nonbarbiturate   

(KLOR-uhl HIGH-drate)

Aquachloral Supprettes

Class: Sedative and hypnotic/nonbarbiturate

Drugs Class ::

 Action Exact mechanism is unknown; can produce mild CNS depression.

Indications for Drugs ::

 Indications Management of short-term insomnia; sedation; adjunctive to anesthesia, analgesia; prevention or suppression of alcohol withdrawal symptoms (rectal). Unlabeled use(s): Conscious sedation in pediatric dentistry.

Drug Dose ::

 Route/Dosage

Insomnia

ADULTS: Po/PR 500 mg-1 g 15–30 min before bedtime. CHILDREN: Po/PR 50 mg/kg/day (up to 1 g per dose) for sleep.

Premedication

ADULTS: PO 500 mg-1 g 30 min before surgery.

Sedation

ADULTS: PO 250 mg tid after meals. CHILDREN: PO/PR 25 mg/kg/day; may be given in divided doses.

Dental Sedation

CHILDREN: 75 mg/kg; supplementation with nitrous oxide may provide better sedation than manufacturer’s recommended dosage.

Contraindication ::

 Contraindications Hypersensitivity to chloral derivatives; severe renal or hepatic impairment; gastritis (oral forms); severe cardiac disease.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Excreted in breast milk. Acute intermittent porphyria: Attacks may be precipitated in susceptible patients. Drug dependency: May be habit forming. Use with caution in patients with history of drug or alcohol addiction. GI disorders: Avoid use in patients with esophagitis, gastritis or gastric or duodenal ulcers. Skin/mucous membrane irritation: Irritates skin and mucous membranes. Tartrazine sensitivity: Some products contain tartrazine, which can cause allergic-type reactions in some individuals.

Drug Side Effects ::

 Adverse Reactions

CNS: Somnambulism; ataxia; dizziness; headache; “hangover” effect. GI: Stomach pain; nausea; vomiting; diarrhea; flatulence; unpleasant taste in mouth. HEMA: Leukopenia; eosinophilia. RESP: Respiratory depression. OTHER: Hypersensitivity (rash, itching, erythema multiforme, fever).

Drug Mode of Action ::  

 Action Exact mechanism is unknown; can produce mild CNS depression.

Drug Interactions ::

 Interactions

Alcohol and other CNS depressants: May produce additive CNS depression. Furosemide (IV): Administration within 24 hr of chloral hydrate may lead to diaphoresis, hot flashes, tachycardia and hypertension. Oral anticoagulants: Anticoagulant effects may be increased, especially during first 2 wk. Phenytoin: May reduce effects of phenytoin.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies. Note history of drug abuse; allergic or hypersensitivity responses to chloral hydrate, tartrazine or aspirin; and history of cardiac or GI disease.
• Institute safety precautions (eg, use of siderails and having call bell within patient’s reach).
• If signs of gastric, liver or renal dysfunction occur, notify physician.
• Observe patient for signs of alertness and signs of psychologic or physical dependence.

Drug Storage/Management ::

 Administration/Storage

• Administer syrup or capsules with full glass of water or fruit juice to help prevent GI or renal problems. Chilling of syrup may lessen its unpleasant taste.
• Store at room temperature in tightly closed, light-resistant container.

Drug Notes ::

 Patient/Family Education

• Instruct patient to take medication exactly as prescribed. Warn that taking doses too close together could result in overdose. Missed doses should be omitted.
• Inform patient that effects of medication may not be noted until after 48 hr.
• Advise that medication will be discontinued gradually to prevent withdrawal symptoms, including CNS excitation with tremor, anxiety, hallucinations or delirium.
• Instruct patient to report these symptoms to physician: visual changes, irregular heartbeats or palpitations, yellowing of skin or eyes, rash or unusual bleeding or bruising, abdominal pains or gastrointestinal problems.
• Advise patient that drug may cause drowsiness or dizziness and to use caution when driving or performing other tasks requiring mental alertness.
• Caution patient to avoid intake of alcoholic beverages and other CNS depressants such as barbiturates and narcotics.
• Instruct patient not to take otc medications without consulting physician.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.