Details About Generic Salt ::  Mezlocil

Main Medicine Class:: Antibiotic,penicillin   

(MEZZ-low-SILL-in SO-dee-uhm)
Mezlin
Class: Antibiotic/penicillin

 

Drugs Class ::

 Action Inhibits biosynthesis of bacterial cell wall mucopeptide.

Indications for Drugs ::

 Indications Treatment of infections of lower respiratory tract, urinary tract, skin or skin structure; intra-abdominal infections; uncomplicated gonorrhea; gynecological infections; septicemia; streptococcal infections; severe infections; and pseudomonas infections caused by susceptible strains of specific microorganisms and prophylaxis.

Drug Dose ::

 Route/Dosage

ADULTS: IM/IV 200 to 300 mg/kg/day in 4 to 6 divided doses. Usual doses are 3 g q 4 hr or 4 g q 6 hr. IM doses should not exceed 2 g/injection. CHILDREN > 1 MO to < 12 YR: IM/IV 50 mg/kg q 4 hr. NEONATES: IV 75 mg/kg q 6 to 12 hr.

Contraindication ::

 Contraindications Hypersensitivity to penicillins.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Bleeding abnormalities: Hemorrhagic manifestations associated with abnormalities of coagulation tests (bleeding time, PT, platelet aggregation) may occur. Abnormalities should revert to normal when drug is discontinued. Hypersensitivity: Reactions range from mild to life threatening. Administer cautiously to cephalosporin-sensitive patients because of possible cross reactivity. Pseudomembranous colitis: Consider in patients with diarrhea. Sodium content: 1.85 mEq sodium/g. Superinfection: May result in bacterial or fungal overgrowth of nonsusceptible organisms.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CNS: Neurotoxicity (eg, lethargy, neuromuscular irritability, hallucinations, convulsions, seizures); dizziness; fatigue; insomnia; reversible hyperactivity; rolonged muscle relaxation. DERM: Ecchymosis. EENT: Itchy eyes. GI: Nausea; vomiting; abdominal pain or cramp; diarrhea or bloody diarrhea; ectal bleeding; flatulence; enterocolitis; pseudomembranous colitis; anorexia. GU: Interstitial nephritis (oliguria, proteinuria, hematuria, hyaline casts, pyuria); nephropathy; elevated creatinine or BUN. HEPA: Transient hepatitis; cholestatic jaundice. HEMA: Anemias; thrombocytopenia; eosinophilia; leukopenia; granulocytopenia; eutropenia; bone marrow depression; agranulocytosis; reduced hemoglobin or hematocrit; prolongation of bleeding time and PT; altered blood cell counts. META: Elevated serum alkaline phosphatase; hypernatremia; reduced serum potassium, albumin, total proteins, and uric acid. OTHER: Hypersensitivity reactions that may lead to death; vaginitis; hyperthermia; ain at site of injection; deep vein thrombosis; hematomas; vein irritation; hlebitis; sciatic neuritis.

Drug Mode of Action ::  

 Action Inhibits biosynthesis of bacterial cell wall mucopeptide.

Drug Interactions ::

 Interactions

Contraceptives, oral: May reduce efficacy of oral contraceptives. Tetracyclines: May impair bactericidal effects of mezlocillin. INCOMPATIBILITIES: Parenteral aminoglycosides may inactivate aminoglycosides in vitro; o not mix in same IV solution.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any allergies.
  • Monitor I&O throughout therapy.
  • Monitor liver function, hematology (WBC, RBC, hgb, hct, bleeding time), and renal function.
  • Assess bowel function.
  • Assess respiratory status.
  • Observe IV site for thrombophlebitis.
  • Notify physician of hemorrhagic manifestations associated with abnormalities in coagulation time.

OVERDOSAGE: SIGNS & SYMPTOMS
  Neuromuscular hyperexcitability, seizures, convulsive seizures, agitation, confusion, asterixis, hallucinations, stupor, coma, multifocal myoclonus, encephalopathy, hyperkalemia

Drug Storage/Management ::

 Administration/Storage

  • For IV administration reconstitute each gram of mezlocillin sodium with 9 to 10 ml of sterile water, D5W, or 0.9% Sodium Chloride Injection; shake vigorously.
  • Temporarily discontinue administration of any other solution during infusion.
  • May inject reconstituted solution ³ 10% into vein or IV tubing; infuse slowly over 3 to 5 min.
  • For IM administration reconstitute each gram of mezlocillin sodium with 3 to 4 ml of 0.5% to 1% lidocaine HCl without epinephrine. Inject into large muscle slowly (12 to 15 sec) to minimize discomfort.
  • Store unreconstituted mezlocillin at room temperature.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to report the following symptoms to physician: kin rash, itching, hives, severe diarrhea, shortness of breath, wheezing, black tongue, sore throat, nausea, vomiting, fever, swollen joints, or any unusual bleeding or bruising.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

DOWNLOAD OUR ANDROID APP

One of the 1st in India.High Quality Generic Medicine Portal Android Application for Online Oreder & Information.

For More Join Our Membership and Get Additional 25% off on Meds, also get MLM Benefits to get a permanent earning source.

Join Membership How to Search Medicine
Android App

We would like to keep you updated with special notifications.