Details About Generic Salt ::  Gabapent

Main Medicine Class:: Anticonvulsant   

Capsules: 100 mg, 300 mg, 400 mg
Class: Anticonvulsant


Drugs Class ::

 Action Mechanism unknown; gabapentin-binding sites have been found in neocortex and hippocampus areas of the brain.

Indications for Drugs ::

 Indications Adjunctive therapy in treatment of partial seizures with or without secondary generalization in patients above 12 yr with epilepsy; adjunctive therapy for partial seizures in children 3 to 12 yr; management of postherpetic neuralgia in adults.

Drug Dose ::



ADULTS AND CHILDREN ABOVE 12 YR: PO 900 to 1800 mg/day in divided doses tid. Initial dose: 300 mg on day 1 and titrate upward rapidly. To minimize CNS side effects, administer initial dose on day 1 at bedtime. CHILDREN 3 TO 12 YR: PO Initiate therapy at 10 to 15 mg/kg/day in divided doses (ie, 3 times/day) and titrate dose upward over a period of about 3 days to the effective dose. CHILDREN AT LEAST 5 YR: PO The effective dose is 25 to 35 mg/kg/day in divided doses (ie, 3 times/day). CHILDREN 3 TO 4 YR: PO The effective dose is 40 mg/kg/day in divided doses (ie, 3 times/day).

Postherpetic Neuralgia

ADULTS: PO Start with a single 300 mg dose on day 1, 600 mg on day 2 (divided twice daily), and 900 mg on day 3 (divided 3 times daily). Subsequently, titrate the dose upward as needed for pain relief to a daily dose of 1800 mg (divided 3 times daily).

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::


Pregnancy: Category C. Lactation: Secreted in breast milk. Children: Safety and efficacy in children below 3 yr not established; safety and efficacy in management of postherpetic neuralgia in pediatric patients not established. Elderly and debilitated patients: Because of age-related renal impairment, dosage adjustment may be required. Carcinogenesis: May have carcinogenic potential. Renal impairment: Dose reduction recommended. Serious adverse effects: During clinical trials, some patients experienced status epilepticus, and 8 sudden, unexplained deaths occurred. The association of these events with gabapentin use is unclear. Withdrawal: Do not discontinue antiepileptic drugs abruptly because of possible increased seizure frequency from drug withdrawal.


Drug Side Effects ::

 Adverse Reactions

CV: Hypertension. CNS: Somnolence; dizziness; ataxia; tremor; nervousness; dysarthria; amnesia; depression; abnormal thinking; twitching; abnormal coordination; vertigo; hyperkinesia; parasthesia; reflex abnormality; hostility; anxiety. DERM: Pruritus; abrasion; purpura. EENT: Diplopia; amblyopia; nystagmus; abnormal vision; gingivitis. GI: Dyspepsia; dry mouth or throat; constipation; dental abnormalities; increased appetite; anorexia; flatulence. RESP: Rhinitis; pharyngitis; coughing; pneumonia. OTHER: Fatigue; weight increase; back pain; peripheral edema; impotence; leukopenia; vasodilation; asthenia; malaise; facial edema; arthralgia.

Drug Mode of Action ::  

 Action Mechanism unknown; gabapentin-binding sites have been found in neocortex and hippocampus areas of the brain.

Drug Interactions ::


Antacids: May reduce bioavailability of gabapentin. Cimetidine: Reduces renal clearance of gabapentin.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies. Note compromised renal and cardiovascular function and seizure pattern.
  • Assess baseline vital signs.
  • Evaluate for reduced renal clearance when administered concurrently with cimetidine.
  • Withdraw medication gradually to avoid the possibility of increasing seizure frequency.
  Ataxia, labored breathing, ptosis, sedation, hypoactivity or excitation, double vision, slurred speech, drowsiness, lethargy, diarrhea

Drug Storage/Management ::


  • Administer medication with or without food and at least 2 hr after antacid administration.
  • Administer initial dose on day 1 at bedtime to minimize CNS side effects.
  • Titrate to effective dose given tid up to 1800 mg/day; maximum time between doses in tid schedule should not exceed 12 hr.
  • Discontinue medication gradually over minimum of 1 wk.
  • Store medication in tightly sealed container.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to take medication at least 2 hr after taking antacid.
  • Explain that missed dose should be taken as soon as remembered but that 2 doses should not be taken together. Instruct patient to call health care provider if at least 2 doses are missed.
  • Instruct patient to report the following symptoms to health care provider: excessive fatigue or weakness, dizziness, somnolence, incoordination, tremor or other symptoms of CNS depression, change in normal behavior, weight gain, back pain, alterations in GI system, alteration in skin or mucous membranes, fluid retention, general body discomfort, anorexia, visual disturbances, impotence.
  • Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


One of the 1st in India.High Quality Generic Medicine Portal Android Application for Online Oreder & Information.

For More Join Our Membership and Get Additional 25% off on Meds, also get MLM Benefits to get a permanent earning source.

Join Membership How to Search Medicine
Android App

We would like to keep you updated with special notifications.