Indications & Dose: BRONCHOSPASM Acute PO Adult Initially 2.5/3mg TID increased to 5mg TID as needed. MR tablet: 7.5mg BID Child 7-15 yr: 2.5mg BID/TID > 15 yr: Same as adult doseWhen inhalation is ineffective | Severe IV Adult Inj: Same as SC/IM, Inf: 3-5µg/mL at 0.5-1mL/min Child Inj: Same as SC, Inf: Initially 2-4µg/kg followed by 1-10µg/kg/h according to response & HR | Severe IM Adult 250-500µg QID | Severe SC Adult Same as IV Child => 2yr: 10µg/kg q6h as required, 2-15 yr: 300µg as single dose, >15 yr: 500µg | Acute Inh Adult 250µg (1 or 2 inhalations) from a metered-dose aerosol q4-6h, max 8 inhalations/day Child => 5 yr: 500µg QID (MDI) | EXACERBATION OF ASTHMA Acute SC Adult 0.25mg may be repeated within 15-30min if no response. Dose >0.5mg should not be used within 4h period Child =< 12 yr: 0.01mg/kg q20min for a total of 3 doses then q2-6h as needed, => 12 yr: 0.25mg/kg q20min for total of 3 doses in hospitalized patients | SEVERE OR UNRESPONSIVE BRONCHOSPASM Inh Adult Nebuliser: 5-10mg inhaled 2-4 times/day Child <3 yr (10 kg): 2mg 2-4 times/day, 3-5 yr (15 kg): 3mg 2-4 times/day, 6-7 yr (20 kg): 4mg 2-4 times/day, 8 yr (>25 kg): 5mg 2-4 times/day

Precautions: Bronchospasm, CVD, asthma, DM, glaucoma, hyperthyroidism, hypokalemia, seizures

ADR: Serious: tachycardia, HTN, May cause hypotension MI, pulmonary edema, hypokalemia in preterm labor, Others: dizziness, drowsiness, headache, insomnia, nervousness, restlessness, hyperglycemia, nausea, vomiting, weakness

DDI: Serious Furosemide/Amphotericin-B increases risk of serious cardiac arrhythmias, Metoprolol/Atenolol inhibits bronchodilator effect, Halothane leads to arrhythmias, Toloxatone/Phenylephrine leads to HTN, sweating, tachycardia & headache, Theophylline/Aminophylline potentiates hypokalemia & tachycardia

Diet: with/without food

Monitor: Serum K+ & glucose, intake/output HR, BP, respiratory rate, PFTs, pulmonary edema (when used as tocolytic)